HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: HOOK3 (Q86VS8)
Protein Hook homolog 3 (h-hook3) (hHK3)
Gene: HOOK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25799409
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005874 - microtubule GO:0008017 - microtubule binding GO:0031122 - cytoplasmic microtubule organization GO:0034452 - dynactin binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 718
+	Hs
		529217 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MYH10_HUMAN (195-718): 3.82e-20: 98.2: 10.76
+	Hs
		530549 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MYH2_HUMAN (423-718): 9.29e-11: 67.7: 10.14
+	Hs
		529216 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MYH9_HUMAN (401-717): 2.24e-10: 66.6: 11.67
+	Hs
		530150 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MY18A_HUMAN (250-691): 1.6e-09: 63.8: 17.03
+	Rn
		620102 TAU_RAT (1-758): 3.21e-76: 263: 72.11		MYH10_RAT (195-718): 2.44e-20: 98.9: 10.57
+	Rn
		98796 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		MYH10_RAT (195-718): 2.44e-20: 98.9: 10.57
+	Ce
		145076 UNC89_CAEEL (4-460): 1.4e-21: 103: 12.35		MYSP_CAEEL (5-692): 2.56e-25: 114: 11.16
+	Hs
		1294691 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		K2C73_HUMAN (277-608): 1.86e-34: 140: 17.42
+	Hs
		551605 NFH_HUMAN (113-708): 1.12e-25: 115: 10.96		MYH9_HUMAN (401-717): 2.24e-10: 66.6: 11.67
+	Hs
		1401420 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		DAPLE_HUMAN (69-718): 4.42e-18: 91.4: 11.26
+	Hs
		1141793 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		EEA1_HUMAN (344-718): 3.74e-13: 75.4: 10.67