HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	37398204, 35063084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0030674 - protein-macromolecule adaptor activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 780
+	Hs
		529762 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		529760 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CUL1_HUMAN (11-780): 0: 746: 27.84
+	Hs
		529761 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		CUL2_HUMAN (6-780): 0: 697: 26.36
+	Hs
		551615 NFH_HUMAN (113-708): 1.12e-25: 115: 10.96		CUL1_HUMAN (11-780): 0: 746: 27.84
+	Hs
		1113373 MUC17_HUMAN (1-559): 4.93e-12: 72.3: 9.70		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		1113479 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		1114070 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		161463 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		1113742 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		1114004 ZN469_HUMAN (2-616): 8.03e-09: 61.6: 9.74		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		698279 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		CUL4A_HUMAN (16-780): 0: 743: 24.48