HitPredict

Interactor 1: MMP9 (P14780)
Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
Gene: MMP9

Interactor 2: TIMP2 (P16035)
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene: TIMP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	enzymatic reaction

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008270 - zinc ion binding GO:0062023 - collagen-containing extracellular matrix GO:1904724 - tertiary granule lumen and 1 others more... GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 707 Hs			1 220
+	Hs
		344786 MMP9_HUMAN (1-707): 0: 862: 100.00		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		439263 MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		439275 MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		372726 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		372742 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		439265 MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		554810 MMP16_HUMAN (45-280): 2.33e-72: 248: 32.35		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		554808 MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		344781 MMP3_HUMAN (8-272): 4.38e-93: 299: 37.46		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		554809 MMP15_HUMAN (45-279): 2.87e-67: 235: 31.02		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		838537 MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		344784 MMP10_HUMAN (6-235): 1.56e-89: 290: 40.41		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		344777 MMP1_HUMAN (31-238): 9.64e-87: 282: 42.67		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		726505 MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		344795 MMP14_HUMAN (33-254): 2.47e-70: 241: 32.43		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		439223 MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		439254 MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		554822 ESPB1_HUMAN (286-393): 1.81e-18: 86.7: 34.26		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		439230 MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		344780 MMP2_HUMAN (576-707): 2.91e-20: 97.5: 15.71		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29