HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.748

The method score is based on:

Property Details
Experiments 20816854, 10903799, 8006584, 1545122, 15178252, 8026467, 8568232, 7681595
Identification Methods fluorescent resonance energy transfer, cross-linking study, coimmunoprecipitation, biophysical, anti tag coimmunoprecipitation, isothermal titration calorimetry, protein cross-linking with a bifunctional reagent
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004896 - cytokine receptor activity
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 10 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 551
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024