HitPredict

Interactor 1: HNRPL (P14866)
Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Gene: HNRNPL

Interactor 2: PTBP1 (P26599)
Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)
Gene: PTBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.868

The method score is based on:

Property Details
Experiments 9563502, 10772858, 35271311
Identification Methods two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RRM_1~RRM_1, RRM_1~RRM_5, RRM_5~RRM_5, RRM_8~RRM_8
Common GO terms GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 4 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 589
Hs

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Last updated: 15 Jul 2024