Protein: HUWE1
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (E3Histone) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)

Gene: HUWE1
Organism: Mus musculus
Interactions: 74
UniProt ID: Q7TMY8

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003677 - DNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509127

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

20

Small-scale

0.696

High

987293

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.691

High

1229295

GIT1
ARF GTPase-activating protein GIT1

1

8

High-throughput

0.691

High

1274320

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

9

High-throughput

0.691

High

1230402

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

14

Small-scale

0.584

High

147423

BIN1
Myc box-dependent-interacting protein 1

1

8

High-throughput

0.536

High

147527

DPYL2
Dihydropyrimidinase-related protein 2

1

10

High-throughput

0.536

High

313377

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

3

High-throughput

0.536

High

548960

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

4

High-throughput

0.536

High

578754

GLNA
Glutamine synthetase

1

2

High-throughput

0.536

High

593890

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

2

High-throughput

0.536

High

659105

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.536

High

694280

XRCC5
X-ray repair cross-complementing protein 5

1

6

High-throughput

0.536

High

704224

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

4

High-throughput

0.536

High

704817

KIF5C
Kinesin heavy chain isoform 5C

1

6

High-throughput

0.536

High

840628

PURA
Transcriptional activator protein Pur-alpha

1

1

High-throughput

0.536

High

945970

EF2
Elongation factor 2

1

10

High-throughput

0.536

High

993939

KPCG
Protein kinase C gamma type

1

14

High-throughput

0.536

High

1000358

TP53B
TP53-binding protein 1

1

8

High-throughput

0.536

High

1013631

TNIK
Traf2 and NCK-interacting protein kinase

1

20

High-throughput

0.536

High

1028516

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

17

High-throughput

0.536

High

1208445

WDR81
WD repeat-containing protein 81

1

3

High-throughput

0.536

High

1223940

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

6

High-throughput

0.536

High

1242753

NEST
Nestin

1

8

High-throughput

0.536

High

1243471

ARHGI
Rho guanine nucleotide exchange factor 18

1

5

High-throughput

0.536

High

1274317

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

5

High-throughput

0.536

High

1274319

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.536

High

1274322

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.536

High

1274324

DP13A
DCC-interacting protein 13-alpha

1

5

High-throughput

0.536

High

1274325

ARHGC
Rho guanine nucleotide exchange factor 12

1

6

High-throughput

0.536

High

1274327

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

3

High-throughput

0.536

High

1274333

TRIM3
Tripartite motif-containing protein 3

1

7

High-throughput

0.536

High

1274335

NOS1
Nitric oxide synthase 1

1

1

High-throughput

0.536

High

236601

ITB3
Integrin beta-3

1

7

High-throughput

0.501

High

772444

CALX
Calnexin

1

5

High-throughput

0.489

High

857227

NSF
Vesicle-fusing ATPase

1

6

High-throughput

0.489

High

1021095

NPTN
Neuroplastin

1

4

High-throughput

0.489

High

1021380

DPYL1
Dihydropyrimidinase-related protein 1

1

10

High-throughput

0.489

High

1240005

MTCL3
Microtubule cross-linking factor 3

1

8

High-throughput

0.489

High

1274310

WDR91
WD repeat-containing protein 91

1

11

High-throughput

0.489

High

1274321

TENR
Tenascin-R

1

2

High-throughput

0.489

High

1274329

DLGP1
Disks large-associated protein 1

1

2

High-throughput

0.489

High

1274332

KI21A
Kinesin-like protein KIF21A

1

5

High-throughput

0.489

High

1274334

E41L3
Band 4.1-like protein 3

1

13

High-throughput

0.489

High

670125

NECD
Necdin

1

9

Small-scale

0.481

High

109322

G5E8T2
E3 ubiquitin-protein ligase TTC3

1

16

High-throughput

0.479

High

373694

MYC
Myc proto-oncogene protein

1

9

Small-scale

0.479

High

382498

P53
Cellular tumor antigen p53

1

14

Small-scale

0.479

High

467765

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.479

High

693453

ETS1
Protein C-ets-1

1

4

Small-scale

0.479

High

847044

H13
Histone H1.3

1

5

Small-scale

0.479

High

1021072

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

1

3

Small-scale

0.479

High

1274318

FACD2
Fanconi anemia group D2 protein homolog

1

3

High-throughput

0.479

High

1274326

EED
Polycomb protein EED

1

8

High-throughput

0.479

High

1274328

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.479

High

1274330

ATAD1
Outer mitochondrial transmembrane helix translocase

1

11

Small-scale

0.479

High

1274331

CAF1A
Chromatin assembly factor 1 subunit A

1

4

High-throughput

0.479

High

927855

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

1225697

ARF
Tumor suppressor ARF

1

0

Small-scale

0.458

High

478532

ITB1
Integrin beta-1

1

14

High-throughput

0.457

High

549391

ITB2
Integrin beta-2

1

12

High-throughput

0.457

High

838304

STAT3
Signal transducer and activator of transcription 3

1

6

High-throughput

0.457

High

312003

TTC3
E3 ubiquitin-protein ligase TTC3

1

12

High-throughput

0.445

High

1246197

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

3

High-throughput

0.445

High

104567

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

4

High-throughput

0.437

High

104763

F7AAP4
Calcium-transporting ATPase

1

3

High-throughput

0.437

High

108728

G3X9H5
Huntingtin

1

4

High-throughput

0.437

High

931824

EPHB3
Ephrin type-B receptor 3

1

9

Small-scale

0.437

High

1225151

GLRA1
Glycine receptor subunit alpha-1

1

1

Small-scale

0.437

High

551450

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.408

High

59055

F1712
Protein FAM171A2

1

0

High-throughput

0.279

Low

1211526

K0319
Dyslexia-associated protein KIAA0319 homolog

1

0

High-throughput

0.279

Low

1274323

MBRL
Membralin

1

0

High-throughput

0.279

Low

1274336

PRAF1
Prenylated Rab acceptor protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025