HitPredict

Interactor 1: SYDC (P14868)
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)
Gene: DARS1

Interactor 2: SYQ (P47897)
Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)
Gene: QARS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017101 - aminoacyl-tRNA synthetase multienzyme complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 775
+	Hs
		814452 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYQ_HUMAN (1-775): 0: 1146: 100.00
+	Dm
		1178636 Q7K0E6_DROME (19-501): 0: 562: 68.66		SYQ_DROME (1-774): 0: 977: 57.36
+	Sc
		389042 SYDC_YEAST (9-501): 0: 530: 56.46		SYQ_YEAST (1-774): 0: 817: 38.36
+	Sc
		526335 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYQ_YEAST (1-774): 0: 817: 38.36
+	Sc
		526320 SYKC_YEAST (12-493): 1.1e-140: 418: 18.88		SYQ_YEAST (1-774): 0: 817: 38.36
+	Dm
		659575 Q7K0E6_DROME (19-501): 0: 562: 68.66		SYEP_DROME (213-752): 0: 610: 30.14
+	Hs
		430959 SYK_HUMAN (14-495): 2.23e-154: 454: 18.88		SYEP_HUMAN (199-761): 0: 685: 30.28
+	Sc
		389109 SYDC_YEAST (9-501): 0: 530: 56.46		SYEC_YEAST (214-767): 0: 589: 29.43
+	Sc
		752848 SYNC_YEAST (5-501): 6.15e-165: 479: 25.44		SYEC_YEAST (214-767): 0: 589: 29.43
+	Sc
		546190 SYKC_YEAST (12-493): 1.1e-140: 418: 18.88		SYEC_YEAST (214-767): 0: 589: 29.43
+	Cj
		222236 SYK_CAMJE (53-493): 2.16e-21: 99: 24.05		SYE2_CAMJE (263-563): 2.13e-102: 325: 21.75