HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: DSG3 (P32926)
Desmoglein-3 (130 kDa pemphigus vulgaris antigen) (PVA) (Cadherin family member 6)
Gene: DSG3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	7738346
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001533 - cornified envelope GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030057 - desmosome GO:0070062 - extracellular exosome and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 999
+	Hs
		542318 PLAK_HUMAN (1-745): 0: 551: 100.00		DSG2_HUMAN (2-992): 0: 804: 37.15
+	Hs
		542286 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC2_HUMAN (27-863): 0: 744: 28.52
+	Hs
		542323 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC3_HUMAN (27-863): 0: 732: 27.34
+	Hs
		542294 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC1_HUMAN (30-863): 0: 697: 27.41
+	Hs
		542178 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH2_HUMAN (44-805): 0: 615: 26.00
+	Hs
		716916 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CAD11_HUMAN (23-804): 0: 642: 23.23
+	Gg
		193807 O42486_CHICK (1-731): 4.63e-176: 525: 67.51		CADH2_CHICK (44-805): 0: 618: 25.48
+	Hs
		716913 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH4_HUMAN (37-805): 0: 624: 26.69
+	Hs
		542490 PLAK_HUMAN (1-745): 0: 551: 100.00		CAD10_HUMAN (11-809): 0: 588: 21.69
+	Hs
		580207 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH2_HUMAN (44-805): 0: 615: 26.00
+	Hs
		716914 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH6_HUMAN (44-809): 0: 608: 22.80
+	Hs
		521702 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH1_HUMAN (42-603): 1.44e-175: 536: 32.17
+	Hs
		542247 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH8_HUMAN (40-627): 4.61e-171: 521: 24.46
+	Hs
		542185 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH3_HUMAN (22-589): 1.46e-169: 518: 29.19
+	Hs
		521758 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH1_HUMAN (42-603): 1.44e-175: 536: 32.17
+	Hs
		542285 PLAK_HUMAN (1-745): 0: 551: 100.00		DSG1_HUMAN (190-992): 2.26e-160: 501: 24.08
+	Cl
		80821 CTNB1_CANLF (1-731): 1.59e-173: 519: 67.38		CADH1_CANLF (39-607): 2.68e-172: 527: 31.61
+	Hs
		716915 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH8_HUMAN (40-627): 4.61e-171: 521: 24.46
+	Hs
		606301 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH3_HUMAN (22-589): 1.46e-169: 518: 29.19
+	Mm
		877530 PLAK_MOUSE (1-745): 0: 553: 98.39		CADH5_MOUSE (40-593): 1.08e-45: 179: 28.67