Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)

Gene: TOP1
Organism: Drosophila melanogaster
Interactions: 37
UniProt ID: P30189

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0002168 - instar larval development
GO:0003677 - DNA binding
GO:0003916 - DNA topoisomerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718363

Q9W124
LD27920p

2

2

High-throughput

0.571

High

718345

TOPRS
E3 ubiquitin-protein ligase Topors

1

2

Small-scale

0.561

High

718349

PPAN
Protein Peter pan

2

0

High-throughput

0.547

High

718343

Q9I7K8
FI07222p

1

9

High-throughput

0.536

High

718351

Q9VGU4
FI02822p

1

9

High-throughput

0.536

High

718364

ZPR1
Zinc finger protein ZPR1

1

0

High-throughput

0.486

High

718333

MOEH
Moesin/ezrin/radixin homolog 1

1

5

High-throughput

0.481

High

718335

KELC
Ring canal kelch protein [Cleaved into: Kelch short protein]

1

1

Small-scale

0.479

High

54867

A1Z909
LD11307p

1

2

High-throughput

0.445

High

718336

Q6NQY9
ATP-dependent RNA helicase

1

5

High-throughput

0.445

High

718337

Q7JQN4
RNA helicase

1

5

High-throughput

0.445

High

718341

Q8SY39
ATP-dependent RNA helicase DDX54

1

7

High-throughput

0.445

High

718348

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

4

High-throughput

0.445

High

718350

Q9VFH2
Hexamethylene bisacetamide inducible, isoform A

1

1

High-throughput

0.445

High

718354

Q9VJG2
RRM domain-containing protein

1

4

High-throughput

0.445

High

718355

RRP1L
Ribosomal RNA processing protein 1 homolog

1

5

High-throughput

0.445

High

718356

Q9VRI0
Probable ATP-dependent RNA helicase DDX56

1

8

High-throughput

0.445

High

718358

Q9VYQ9
Pleiotropic regulator 1

1

5

High-throughput

0.445

High

718359

Q9VZ88
AT07585p

1

8

High-throughput

0.445

High

718360

Q9VZF5
Kinesin-like protein

1

5

High-throughput

0.445

High

718365

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.445

High

355841

TOP3B
DNA topoisomerase 3-beta

1

0

High-throughput

0.426

High

718339

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

718340

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.426

High

718342

Q94513
Boundary element associated factor

1

0

Small-scale

0.426

High

718344

Q9V426
LD07162p

1

0

High-throughput

0.426

High

718346

NEMF
Ribosome quality control complex subunit NEMF homolog

1

0

High-throughput

0.426

High

718347

Q9VC93
Exosome complex exonuclease RRP44

1

0

High-throughput

0.426

High

718352

Q9VGZ2
FI06805p

1

0

High-throughput

0.426

High

718353

Q9VHM3
LD30467p

1

0

High-throughput

0.426

High

718366

ZN593
Zinc finger protein 593 homolog

1

0

High-throughput

0.426

High

718361

Q9W0R0
Cell division cycle 5, isoform A

1

4

High-throughput

0.407

High

718362

Q9W108
FI01540p

1

4

High-throughput

0.407

High

718334

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.232

Low

718338

Q7K0L8
FLICE-associated huge protein, isoform A

1

0

High-throughput

0.232

Low

718357

Q9VT38
GH03795p

1

0

High-throughput

0.232

Low

718367

Q9W4K1
AP-3 complex subunit beta

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025