HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: STI1 (P15705)
Heat shock protein STI1
Gene: STI1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	7929182, 16219779, 19536198, 20237159, 20479121, 21170051, 22227520, 16554755, 17101799, 31399574, 33789348, 37295430, 37453059, 37968396, 20159554, 22354036, 15766533, 16429126
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005737 - cytoplasm GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 589
+	Hs
		437930 HS90B_HUMAN (5-705): 0: 1022: 61.15		STIP1_HUMAN (2-587): 4.47e-82: 269: 34.58
+	Hs
		111934 K9JA46_HUMAN (4-705): 0: 1013: 60.67		STIP1_HUMAN (2-587): 4.47e-82: 269: 34.58
+	Hs
		431574 HS90A_HUMAN (4-705): 0: 1013: 60.67		STIP1_HUMAN (2-587): 4.47e-82: 269: 34.58
+	Hs
		438464 HS90B_HUMAN (5-705): 0: 1022: 61.15		DNJC7_HUMAN (2-237): 2.46e-20: 96.5: 17.16
+	Hs
		431797 HS90A_HUMAN (4-705): 0: 1013: 60.67		IFT88_HUMAN (121-581): 6.69e-22: 102: 11.95
+	Hs
		213454 HS90B_HUMAN (5-705): 0: 1022: 61.15		SGTA_HUMAN (184-385): 1.06e-18: 89.1: 23.04
+	Mm
		513680 HS90B_MOUSE (5-705): 0: 1025: 61.57		PPP5_MOUSE (241-391): 1.37e-16: 84.9: 21.57
+	Hs
		432195 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJC7_HUMAN (2-237): 2.46e-20: 96.5: 17.16
+	Hs
		438021 HS90B_HUMAN (5-705): 0: 1022: 61.15		PPP5_HUMAN (241-400): 1.03e-16: 85.3: 20.99
+	Hs
		174561 HS90B_HUMAN (5-705): 0: 1022: 61.15		OGT1_HUMAN (6-263): 4.81e-16: 83.9: 9.69
+	Hs
		213451 HS90A_HUMAN (4-705): 0: 1013: 60.67		SGTA_HUMAN (184-385): 1.06e-18: 89.1: 23.04
+	Hs
		111935 K9JA46_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (241-400): 1.03e-16: 85.3: 20.99
+	Hs
		431681 HS90A_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (241-400): 1.03e-16: 85.3: 20.99
+	Hs
		174556 HS90A_HUMAN (4-705): 0: 1013: 60.67		OGT1_HUMAN (6-263): 4.81e-16: 83.9: 9.69
+	Mm
		432427 HS90A_MOUSE (4-705): 0: 1012: 60.59		PPP5_MOUSE (241-391): 1.37e-16: 84.9: 21.57
+	Hs
		438533 HS90B_HUMAN (5-705): 0: 1022: 61.15		RPAP3_HUMAN (138-482): 4.15e-12: 71.2: 11.78
+	Hs
		297025 HS90B_HUMAN (5-705): 0: 1022: 61.15		TOM70_HUMAN (74-558): 5.83e-12: 70.4: 10.37
+	Hs
		431774 HS90A_HUMAN (4-705): 0: 1013: 60.67		SPAG1_HUMAN (107-370): 1.43e-13: 75.8: 13.26
+	Hs
		432268 HS90A_HUMAN (4-705): 0: 1013: 60.67		RPAP3_HUMAN (138-482): 4.15e-12: 71.2: 11.78
+	Hs
		297024 HS90A_HUMAN (4-705): 0: 1013: 60.67		TOM70_HUMAN (74-558): 5.83e-12: 70.4: 10.37