HitPredict

Interactor 1: ERF3A (P15170)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Gene: GSPT1

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	12865429
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 618
+	Hs
		545848 ERF3A_HUMAN (1-499): 0: 567: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		545837 ERF3A_HUMAN (1-499): 0: 567: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		932681 EF1A1_HUMAN (70-498): 1.24e-175: 503: 38.29		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Mm
		486085 EF1A1_MOUSE (70-498): 1.27e-175: 503: 38.29		MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21
+	Hs
		932657 EF1A1_HUMAN (70-498): 1.24e-175: 503: 38.29		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Dm
		399186 EF1A2_DROME (70-494): 4.72e-173: 496: 37.73		DIAP2_DROME (261-462): 3.99e-12: 70.8: 16.99
+	Dm
		444575 EF1A1_DROME (70-499): 3.29e-172: 495: 38.88		DIAP2_DROME (261-462): 3.99e-12: 70.8: 16.99