HitPredict

Interactor 1: VATB1 (P15313)
V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)
Gene: ATP6V1B1

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007035 - vacuolar acidification GO:0016241 - regulation of macroautophagy GO:0016471 - vacuolar proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:1902600 - proton transmembrane transport
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 856
+	Hs
		547352 VATB1_HUMAN (1-513): 0: 650: 100.00		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		597713 VATB2_HUMAN (21-503): 0: 594: 88.61		VPP2_HUMAN (1-856): 0: 1320: 100.00
+	Hs
		547359 VATB1_HUMAN (1-513): 0: 650: 100.00		VPP4_HUMAN (1-843): 0: 1227: 51.89
+	Hs
		597688 VATB2_HUMAN (21-503): 0: 594: 88.61		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Mm
		1265223 VATB1_MOUSE (1-513): 0: 646: 93.76		VPP4_MOUSE (1-843): 0: 1224: 52.48
+	Hs
		597702 VATB2_HUMAN (21-503): 0: 594: 88.61		VPP4_HUMAN (1-843): 0: 1227: 51.89
+	Hs
		597661 VATB2_HUMAN (21-503): 0: 594: 88.61		VPP3_HUMAN (1-843): 0: 1082: 49.35
+	Sc
		555906 VATB_YEAST (17-498): 0: 581: 76.97		VPP1_YEAST (3-842): 0: 1037: 36.46
+	Sc
		555981 VATB_YEAST (17-498): 0: 581: 76.97		VPP2_YEAST (3-845): 0: 947: 33.19