HitPredict

Interactor 1: ATF2 (P15336)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Interactor 2: MK09 (P45984)
Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (JNK-55) (Stress-activated protein kinase 1a) (SAPK1a) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2)
Gene: MAPK9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.759

Property	Details
Experiments	25416956, 11865055, 32296183, 16533805, 8654373, 17875713, 12788955, 15192015, 31515488, unassigned1304
Identification Methods	two hybrid, enzymatic study, pull down, protein kinase assay, in-gel kinase assay, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0007254 - JNK cascade GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 424
+	Hs
		547757 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Hs
		547742 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Mm
		562984 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK09_MOUSE (1-424): 1.69e-161: 463: 96.70
+	Hs
		173828 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK13_HUMAN (10-365): 2.72e-135: 394: 46.93
+	Hs
		547805 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK11_HUMAN (8-363): 3.93e-133: 388: 47.08
+	Hs
		547811 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK14_HUMAN (4-375): 9.3e-130: 379: 48.00
+	Mm
		562982 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK08_MOUSE (1-380): 8.38e-145: 419: 83.42
+	Mm
		562985 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK11_MOUSE (8-372): 8.83e-134: 390: 45.92
+	Hs
		568251 ATF7_HUMAN (19-500): 5.33e-94: 295: 54.29		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Rn
		102456 ATF2_RAT (19-505): 5.14e-115: 350: 98.36		G3V617_RAT (4-375): 2.38e-130: 381: 48.00
+	Mm
		562973 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK14_MOUSE (4-375): 3.76e-130: 381: 48.00
+	Hs
		547713 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50
+	Mm
		562980 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK03_MOUSE (20-370): 8.49e-83: 260: 40.56
+	Mm
		562975 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		MK01_MOUSE (15-364): 3.12e-82: 258: 40.22
+	Hs
		568074 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK09_HUMAN (1-424): 2.83e-163: 467: 100.00
+	Hs
		568080 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK10_HUMAN (1-424): 1.16e-155: 449: 84.04
+	Hs
		568073 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Hs
		566734 JUNB_HUMAN (87-425): 4.14e-34: 133: 15.79		MK08_HUMAN (1-424): 1.17e-153: 443: 80.80
+	Sp
		857024 ATF1_SCHPO (174-427): 3.42e-35: 140: 26.67		HOG1_SCHPO (7-364): 3.34e-128: 375: 41.11
+	Hs
		568066 JUND_HUMAN (154-425): 2.88e-35: 136: 19.36		MK01_HUMAN (15-364): 1.35e-82: 259: 40.50