Protein: L1CAM
Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171)

Gene: L1CAM
Organism: Homo sapiens
Interactions: 65
UniProt ID: P32004

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0006935 - chemotaxis
GO:0007155 - cell adhesion
GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164262

NRP1
Neuropilin-1

2

5

Small-scale

0.767

High

731917

ANK2
Ankyrin-2

1

8

High-throughput

0.691

High

731920

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.691

High

731941

BTNL2
Butyrophilin-like protein 2

1

15

High-throughput

0.691

High

124249

HAX1
HCLS1-associated protein X-1

3

1

High-throughput

0.667

High

158529

NCAN
Neurocan core protein

1

3

Small-scale

0.647

High

541362

FGFR1
Fibroblast growth factor receptor 1

1

5

Small-scale

0.647

High

731918

CNTN2
Contactin-2

1

17

Small-scale

0.647

High

249033

NRP2
Neuropilin-2

1

2

Small-scale

0.621

High

731912

L1CAM
Neural cell adhesion molecule L1

1

18

Small-scale

0.621

High

362852

EGFR
Epidermal growth factor receptor

1

10

Small-scale

0.618

High

410658

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

Small-scale

0.618

High

411450

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.618

High

641500

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

11

Small-scale

0.618

High

731925

DGUOK
Deoxyguanosine kinase, mitochondrial

3

1

High-throughput

0.609

High

731939

KTU
Protein kintoun

3

2

High-throughput

0.609

High

731940

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.609

High

480724

LEG1
Galectin-1

2

11

High-throughput

0.601

High

582683

EZRI
Ezrin

2

10

Small-scale

0.595

High

731927

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

731944

FBX2
F-box only protein 2

2

3

High-throughput

0.549

High

731914

GPM6A
Neuronal membrane glycoprotein M6-a

1

1

High-throughput

0.536

High

731921

PTC1
Protein patched homolog 1

1

1

High-throughput

0.536

High

731937

CBLN4
Cerebellin-4

1

3

High-throughput

0.536

High

105435

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

731936

FBX6
F-box only protein 6

2

3

High-throughput

0.521

High

142286

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.514

High

447990

ITAV
Integrin alpha-V

1

1

Small-scale

0.501

High

473666

ITA5
Integrin alpha-5

1

1

Small-scale

0.501

High

208117

PLXB1
Plexin-B1

1

8

Small-scale

0.481

High

731934

RANB9
Ran-binding protein 9

1

3

Small-scale

0.481

High

731942

PLXA1
Plexin-A1

1

7

Small-scale

0.481

High

178194

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

217882

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

344633

AP2A1
AP-2 complex subunit alpha-1

1

2

Small-scale

0.479

High

731913

NUMB
Protein numb homolog

1

2

Small-scale

0.479

High

731938

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

731943

RABX5
Rab5 GDP/GTP exchange factor

1

0

Small-scale

0.458

High

254841

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

404700

PRIO
Major prion protein

1

3

High-throughput

0.445

High

529196

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

609594

LEG3
Galectin-3

1

11

High-throughput

0.445

High

641917

CD9
CD9 antigen

1

4

High-throughput

0.445

High

731915

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

731922

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

5

High-throughput

0.445

High

731928

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

1

High-throughput

0.445

High

731945

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

698426

CALX
Calnexin

1

2

Small-scale

0.437

High

731916

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

731923

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.437

High

127007

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

731929

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

170675

CLGN
Calmegin

1

2

High-throughput

0.407

High

505801

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

1

High-throughput

0.407

High

731933

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.407

High

731924

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.282

High

569587

CATE
Cathepsin E

1

0

High-throughput

0.279

Low

731926

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

731930

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

369162

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.232

Low

731919

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

731931

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

731932

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.232

Low

731935

LMA2L
VIP36-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025