HitPredict - High confidence protein-protein interactions

Interactor 1: VEGFA (P15692)
Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]
Gene: VEGFA

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.988

Property	Details
Experiments	19818105, 28303365, 16901919, 30236477, 12716911, 18325345, 16423422, 8631822, 11333271, 8621427, 9556609, 20145116, 21596751, 22897854, 16763549, 1417831, 31932617, 23374253, 20660291
Identification Methods	pull down, fluorescent resonance energy transfer, enzymatic study, biochemical, coimmunoprecipitation, biophysical, affinity chromatography technology, isothermal titration calorimetry, surface plasmon resonance, solid phase assay and 4 others more... saturation binding, cross-linking study, filter binding, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDGF~ig
Common GO terms	GO:0001525 - angiogenesis GO:0001541 - ovarian follicle development GO:0001569 - branching involved in blood vessel morphogenesis GO:0001570 - vasculogenesis GO:0001934 - positive regulation of protein phosphorylation and 29 others more... GO:0001938 - positive regulation of endothelial cell proliferation GO:0002042 - cell migration involved in sprouting angiogenesis GO:0002070 - epithelial cell maturation GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum GO:0005794 - Golgi apparatus GO:0008284 - positive regulation of cell population proliferation GO:0008360 - regulation of cell shape GO:0010595 - positive regulation of endothelial cell migration GO:0010629 - negative regulation of gene expression GO:0030335 - positive regulation of cell migration GO:0035924 - cellular response to vascular endothelial growth factor stimulus GO:0036324 - vascular endothelial growth factor receptor-2 signaling pathway GO:0038084 - vascular endothelial growth factor signaling pathway GO:0043066 - negative regulation of apoptotic process GO:0043129 - surfactant homeostasis GO:0043410 - positive regulation of MAPK cascade GO:0043536 - positive regulation of blood vessel endothelial cell migration GO:0045766 - positive regulation of angiogenesis GO:0048010 - vascular endothelial growth factor receptor signaling pathway GO:0050927 - positive regulation of positive chemotaxis GO:0051894 - positive regulation of focal adhesion assembly GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0061042 - vascular wound healing GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0090050 - positive regulation of cell migration involved in sprouting angiogenesis GO:1901532 - regulation of hematopoietic progenitor cell differentiation GO:2001028 - positive regulation of endothelial cell chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	395
Hs

1	1356

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Last updated: 15 Jul 2024