Protein: SYMC
Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)

Gene: SYMC, MARS1
Organism: Homo sapiens
Interactions: 202
UniProt ID: P56192

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004825 - methionine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880186

SYLC
Leucine--tRNA ligase, cytoplasmic

3

12

High-throughput

0.861

High

880099

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

2

Small-scale

0.754

High

782994

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.691

High

346347

MYC
Myc proto-oncogene protein

4

3

High-throughput

0.686

High

369265

ESR1
Estrogen receptor

4

4

Small-scale

0.672

High

132798

SDCB1
Syntenin-1

3

1

High-throughput

0.667

High

528845

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

226994

PRKN
E3 ubiquitin-protein ligase parkin

3

8

High-throughput

0.640

High

814408

SYQ
Glutamine--tRNA ligase

2

9

High-throughput

0.628

High

867678

SYRC
Arginine--tRNA ligase, cytoplasmic

2

4

High-throughput

0.628

High

880096

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

11

High-throughput

0.628

High

880116

SYK
Lysine--tRNA ligase

2

9

High-throughput

0.628

High

880105

CUL3
Cullin-3

2

6

High-throughput

0.611

High

201580

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

7

Small-scale

0.590

High

841593

CDK9
Cyclin-dependent kinase 9

2

5

High-throughput

0.584

High

880180

ANLN
Anillin

2

1

High-throughput

0.584

High

581582

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

159181

CSKP
Peripheral plasma membrane protein CASK

1

3

High-throughput

0.541

High

202853

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

418083

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

440438

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.536

High

537615

NCF1
Neutrophil cytosol factor 1

1

4

High-throughput

0.536

High

805893

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.536

High

813279

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

828681

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

880084

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.536

High

880087

RACK1
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.536

High

880104

CUL1
Cullin-1

1

6

High-throughput

0.536

High

880109

CAPR1
Caprin-1

1

1

High-throughput

0.536

High

880113

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

880119

PKN2
Serine/threonine-protein kinase N2

1

7

High-throughput

0.536

High

880137

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.536

High

880139

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.536

High

880148

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

880177

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.536

High

880193

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

880199

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.536

High

880189

DUX4
Double homeobox protein 4

1

3

High-throughput

0.516

High

617492

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.515

High

779108

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

880102

ILK
Integrin-linked protein kinase

1

2

High-throughput

0.515

High

880204

USH1C
Harmonin

1

2

High-throughput

0.515

High

255084

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

739046

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

880122

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

880196

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

788792

RS27
Small ribosomal subunit protein eS27

1

3

High-throughput

0.508

High

620316

GATA2
Endothelial transcription factor GATA-2

1

1

High-throughput

0.500

High

158170

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.493

High

880200

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.493

High

880118

P2RY6
P2Y purinoceptor 6

1

3

High-throughput

0.489

High

533589

TNNT1
Troponin T, slow skeletal muscle

1

0

High-throughput

0.486

High

119288

LEG9
Galectin-9

1

1

High-throughput

0.479

High

122597

MEN1
Menin

1

1

High-throughput

0.479

High

125288

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

148586

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

294591

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

303055

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

322386

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

338196

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

880100

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

10

High-throughput

0.479

High

880101

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

880103

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

880106

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

354386

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

362979

FINC
Fibronectin

1

2

High-throughput

0.479

High

379175

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

384575

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

386400

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

397872

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

403136

LA
Lupus La protein

1

2

High-throughput

0.479

High

429861

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

475536

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

488632

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.479

High

530536

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

569474

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

585641

TFE3
Transcription factor E3

1

1

High-throughput

0.479

High

668552

PML
Protein PML

1

3

High-throughput

0.479

High

684566

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

718664

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

738184

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

4

High-throughput

0.479

High

749293

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

785795

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

808437

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

821959

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

827887

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

835615

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

868100

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

870715

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

880085

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

880086

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

880088

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

880089

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

5

High-throughput

0.479

High

880090

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.479

High

880091

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

880092

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

880094

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

880097

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

880098

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

880111

CUL7
Cullin-7

1

1

High-throughput

0.479

High

880114

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

880115

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

880120

CRY1
Cryptochrome-1

1

3

High-throughput

0.479

High

880121

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

880123

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

880124

CRY2
Cryptochrome-2

1

3

High-throughput

0.479

High

880125

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

880126

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

880127

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

880128

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

880130

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

880131

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

880133

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

880134

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

880138

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

880141

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

880142

LNX1
E3 ubiquitin-protein ligase LNX

1

2

Small-scale

0.479

High

880145

RBCC1
RB1-inducible coiled-coil protein 1

1

4

High-throughput

0.479

High

880146

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

880149

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

880151

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.479

High

880152

FBXW7
F-box/WD repeat-containing protein 7

1

5

Small-scale

0.479

High

880154

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

880155

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

880158

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

880159

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

880160

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.479

High

880161

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

High-throughput

0.479

High

880163

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

8

High-throughput

0.479

High

880164

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

880167

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

880169

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

880172

CHM4B
Charged multivesicular body protein 4b

1

2

High-throughput

0.479

High

880174

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

880176

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

6

High-throughput

0.479

High

880178

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

880179

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

880181

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

880182

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

880183

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

880185

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

880187

WRP73
WD repeat-containing protein WRAP73

1

3

High-throughput

0.479

High

880190

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

880191

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

880192

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

880195

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

880201

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

880202

RBM8A
RNA-binding protein 8A

1

4

High-throughput

0.479

High

880203

NEMO
NF-kappa-B essential modulator

1

6

High-throughput

0.479

High

880175

BRF2
Transcription factor IIIB 50 kDa subunit

1

2

High-throughput

0.470

High

209810

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

648698

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

832275

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

880095

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

880107

BYST
Bystin

1

0

High-throughput

0.458

High

880112

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

880117

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.458

High

880135

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

880140

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

880143

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

880170

STMN4
Stathmin-4

1

0

High-throughput

0.458

High

880083

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.457

High

431697

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.457

High

568196

TAL1
T-cell acute lymphocytic leukemia protein 1

1

1

High-throughput

0.457

High

373953

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.445

High

496665

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

853832

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.445

High

880082

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.445

High

880173

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

880197

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

829441

PPM1F
Protein phosphatase 1F

1

0

High-throughput

0.438

High

182636

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

329549

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

552357

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

650800

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

720092

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

823768

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

877661

FOXA1
Hepatocyte nuclear factor 3-alpha

1

14

High-throughput

0.437

High

880093

TLE2
Transducin-like enhancer protein 2

1

8

High-throughput

0.437

High

880108

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

880110

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

880129

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

880132

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

880136

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.437

High

880150

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

880153

LENG1
Leukocyte receptor cluster member 1

1

1

High-throughput

0.437

High

880162

Q9BPW0
Serine/threonine-protein phosphatase

1

1

High-throughput

0.437

High

880168

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

880188

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

880194

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.437

High

880198

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

880165

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

3

High-throughput

0.417

High

831150

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

994

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

401716

JUN
Transcription factor Jun

1

9

High-throughput

0.407

High

880156

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

880157

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

880166

TM147
BOS complex subunit TMEM147

1

0

High-throughput

0.279

Low

880171

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

880144

OXER1
Oxoeicosanoid receptor 1

1

0

High-throughput

0.269

Low

880147

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

880184

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024