HitPredict

Interactor 1: RAG1 (P15918)
V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]
Gene: RAG1

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10490593
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0033151 - V(D)J recombination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1043 Hs			1 209
+	Hs
		449522 RAG1_HUMAN (1-1043): 0: 1703: 100.00		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		617336 COP1_HUMAN (278-587): 9.57e-53: 200: 20.48		SP100_HUMAN (25-174): 1.61e-31: 122: 74.67
+	Hs
		449794 TRI11_HUMAN (278-618): 9.47e-40: 156: 18.21		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		818273 COP1_HUMAN (278-587): 9.57e-53: 200: 20.48		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Hs
		643420 TRAF6_HUMAN (281-424): 2.9e-29: 125: 22.00		HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00
+	Hs
		817987 TRI26_HUMAN (278-501): 1.93e-37: 150: 16.52		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Mm
		548983 TR30A_MOUSE (279-460): 2.46e-35: 143: 16.50		SOX17_MOUSE (4-90): 2.02e-23: 98.2: 21.84
+	Hs
		537081 TRI27_HUMAN (278-550): 6.23e-38: 151: 13.59		HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92
+	Hs
		1252496 LNX1_HUMAN (258-402): 6.57e-27: 120: 24.66		HM20A_HUMAN (64-203): 2.16e-17: 81: 22.92
+	Dm
		1363819 Q9VJW5_DROME (283-526): 7.42e-37: 143: 22.43		Q9VDL2_DROME (77-173): 1.84e-09: 57.8: 22.68
+	Mm
		101543 RN138_MOUSE (288-386): 9.39e-30: 120: 25.00		F8VQD1_MOUSE (81-181): 8.2e-15: 74.4: 32.67
+	Hs
		567763 TRI31_HUMAN (278-550): 3.89e-33: 135: 13.26		UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72
+	Hs
		567709 RN151_HUMAN (283-407): 4.57e-26: 110: 21.26		UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72
+	Hs
		1223389 TRI22_HUMAN (34-242): 5.38e-15: 81: 14.48		CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45
+	Hs
		585039 RO52_HUMAN (79-206): 1.07e-12: 73.7: 12.40		CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45
+	Hs
		567652 BRCA1_HUMAN (291-361): 2.22e-09: 63.9: 28.77		UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72