Protein: APLP2
Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)

Gene: APLP2
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q06481

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005634 - nucleus
GO:0005788 - endoplasmic reticulum lumen
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127059

APBB1
Amyloid beta precursor protein binding family B member 1

5

15

Small-scale

0.923

High

1055338

APBB2
Amyloid beta precursor protein binding family B member 2

5

15

Small-scale

0.919

High

342401

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

4

15

Small-scale

0.897

High

355076

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

4

13

Small-scale

0.890

High

628405

KLK2
Kallikrein-2

3

12

High-throughput

0.861

High

421979

A4
Amyloid-beta precursor protein

2

15

Small-scale

0.806

High

1055349

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

11

High-throughput

0.726

High

1055301

APLP2
Amyloid beta precursor like protein 2

1

14

Small-scale

0.724

High

1055373

BTNL2
Butyrophilin-like protein 2

1

7

High-throughput

0.691

High

1055379

ST14
Suppressor of tumorigenicity 14 protein

1

15

High-throughput

0.691

High

907309

APLP1
Amyloid beta precursor like protein 1

1

12

Small-scale

0.681

High

1055344

PGCB
Brevican core protein

1

9

High-throughput

0.665

High

168400

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

1055357

SIRPD
Signal-regulatory protein delta

1

0

High-throughput

0.656

High

286363

DAB1
Disabled homolog 1

1

17

Small-scale

0.647

High

1022151

DAB2
Disabled homolog 2

1

16

Small-scale

0.647

High

1055313

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.646

High

429770

JUN
Transcription factor Jun

2

6

High-throughput

0.640

High

584524

VAV
Proto-oncogene vav

2

6

High-throughput

0.628

High

1055361

KLK15
Kallikrein-15

1

14

High-throughput

0.618

High

603250

KPCA
Protein kinase C alpha type

2

6

Small-scale

0.611

High

607577

PTN2
Tyrosine-protein phosphatase non-receptor type 2

2

4

High-throughput

0.611

High

375440

RASK
GTPase KRas

2

13

High-throughput

0.584

High

289078

DEDD
Death effector domain-containing protein

1

1

High-throughput

0.578

High

254985

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.575

High

939488

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.574

High

395974

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

577430

ETS1
Protein C-ets-1

1

12

High-throughput

0.561

High

603643

JUNB
Transcription factor JunB

1

6

High-throughput

0.561

High

1055327

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

960091

RL26
Large ribosomal subunit protein uL24

1

2

High-throughput

0.541

High

336942

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.536

High

423765

APOD
Apolipoprotein D

1

2

High-throughput

0.536

High

506840

CFC1
Cryptic protein

1

3

High-throughput

0.536

High

567838

PRG2
Bone marrow proteoglycan

1

10

High-throughput

0.536

High

586178

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

1

2

High-throughput

0.536

High

960406

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.536

High

1055311

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.536

High

1055316

DUS5
Dual specificity protein phosphatase 5

1

5

High-throughput

0.536

High

1055318

GXLT1
Glucoside xylosyltransferase 1

1

2

High-throughput

0.536

High

1055324

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

1055325

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

1055332

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

1055336

CLC2B
C-type lectin domain family 2 member B

1

11

High-throughput

0.536

High

1055341

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

1055342

ESPB1
Epididymal sperm-binding protein 1

1

8

High-throughput

0.536

High

1055343

MRAP2
Melanocortin-2 receptor accessory protein 2

1

1

High-throughput

0.536

High

1055360

CHST8
Carbohydrate sulfotransferase 8

1

1

High-throughput

0.536

High

1055365

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

596061

H12
Histone H1.2

1

3

High-throughput

0.515

High

387413

APOE
Apolipoprotein E

1

5

High-throughput

0.515

High

407613

S100B
Protein S100-B

1

3

High-throughput

0.515

High

440508

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.515

High

658596

KS6B1
Ribosomal protein S6 kinase beta-1

1

11

High-throughput

0.515

High

849148

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.515

High

1014482

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.515

High

1055312

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.515

High

1055314

LRP8
Low-density lipoprotein receptor-related protein 8

1

12

High-throughput

0.515

High

1055331

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

High-throughput

0.515

High

1055351

ERP44
Endoplasmic reticulum resident protein 44

1

7

High-throughput

0.515

High

1055354

TM2D1
TM2 domain-containing protein 1

1

2

High-throughput

0.515

High

230785

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

1055315

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1055335

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.513

High

1055348

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

1055352

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

1055363

PROK2
Prokineticin-2

1

0

High-throughput

0.513

High

1055369

GINM1
Glycoprotein integral membrane protein 1

1

0

High-throughput

0.513

High

1055378

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.513

High

169523

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

6

Small-scale

0.501

High

443328

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.501

High

482607

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

6

Small-scale

0.501

High

507868

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

799025

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.501

High

853659

MK08
Mitogen-activated protein kinase 8

1

8

Small-scale

0.501

High

1055340

MED12
Mediator of RNA polymerase II transcription subunit 12

1

5

Small-scale

0.501

High

1055377

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.500

High

1055302

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.493

High

548002

PSPC
Surfactant protein C

1

1

High-throughput

0.489

High

570664

EDN3
Endothelin-3

1

1

High-throughput

0.489

High

611090

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.489

High

647472

UD14
UDP-glucuronosyltransferase 1A4

1

3

High-throughput

0.489

High

1055322

UD3A1
UDP-glucuronosyltransferase 3A1

1

3

High-throughput

0.489

High

1055328

SYDE1
Rho GTPase-activating protein SYDE1

1

7

High-throughput

0.489

High

1055358

CSTL1
Cystatin-like 1

1

6

High-throughput

0.489

High

1055362

UD17
UDP-glucuronosyltransferase 1A7

1

3

High-throughput

0.489

High

1055339

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.481

High

1055356

S13A1
Solute carrier family 13 member 1

1

1

Small-scale

0.481

High

218093

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

373896

RASN
GTPase NRas

1

13

High-throughput

0.479

High

400701

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

626196

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

High-throughput

0.479

High

719540

NKTR
NK-tumor recognition protein

1

4

High-throughput

0.479

High

730532

1433S
14-3-3 protein sigma

1

6

High-throughput

0.479

High

761210

RYK
Tyrosine-protein kinase RYK

1

10

Small-scale

0.479

High

856655

BAG6
Large proline-rich protein BAG6

1

10

Small-scale

0.479

High

868676

LEG7
Galectin-7

1

5

High-throughput

0.479

High

904633

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

951115

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

1051655

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

Small-scale

0.479

High

1055303

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1055304

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

9

Small-scale

0.479

High

1055306

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

Small-scale

0.479

High

1055309

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

1055310

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1055317

CAH9
Carbonic anhydrase 9

1

2

High-throughput

0.479

High

1055326

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1055333

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

1055334

RN128
E3 ubiquitin-protein ligase RNF128

1

5

High-throughput

0.479

High

1055364

SPON1
Spondin-1

1

8

Small-scale

0.479

High

1055371

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

1055372

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1055376

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

63135

CL18A
C-type lectin domain family 18 member A

1

7

High-throughput

0.470

High

570401

GFAP
Glial fibrillary acidic protein

1

6

High-throughput

0.470

High

1055305

STX5
Syntaxin-5

1

9

High-throughput

0.470

High

1055308

TCOF
Treacle protein

1

3

High-throughput

0.470

High

1055346

MARK4
MAP/microtubule affinity-regulating kinase 4

1

3

High-throughput

0.470

High

1055353

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

2

High-throughput

0.470

High

1055345

Z512B
Zinc finger protein 512B

1

10

High-throughput

0.464

High

1055350

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

1055367

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.458

High

948801

CD81
CD81 antigen

1

3

High-throughput

0.445

High

1055319

S39AC
Zinc transporter ZIP12

1

9

High-throughput

0.445

High

1055320

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.445

High

1055323

S39A4
Zinc transporter ZIP4

1

9

High-throughput

0.445

High

1055329

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.445

High

1055337

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.445

High

1055347

MF14A
Hippocampus abundant transcript 1 protein

1

14

High-throughput

0.445

High

1055366

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

Small-scale

0.445

High

1055375

S39AA
Zinc transporter ZIP10

1

9

High-throughput

0.445

High

1055321

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.437

High

1055330

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

2

High-throughput

0.437

High

1055355

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

8

High-throughput

0.407

High

1055359

S35B3
Adenosine 3'-phospho 5'-phosphosulfate transporter 2

1

3

High-throughput

0.407

High

1055374

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

598727

ANFB
Natriuretic peptides B

1

0

High-throughput

0.279

Low

1055307

NOGG
Noggin

1

0

High-throughput

0.279

Low

1055368

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1055370

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025