HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: MESP2 (Q0VG99)
Mesoderm posterior protein 2 (Class C basic helix-loop-helix protein 6) (bHLHc6)
Gene: MESP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 397
+	Hs
		1012646 HTF4_HUMAN (3-654): 0: 763: 49.35		MESP2_HUMAN (1-397): 0: 626: 100.00
+	Hs
		551133 ITF2_HUMAN (1-654): 0: 758: 50.07		MESP2_HUMAN (1-397): 0: 626: 100.00
+	Hs
		551572 TFE2_HUMAN (1-654): 0: 907: 100.00		MESP1_HUMAN (32-234): 8.44e-74: 232: 64.53
+	Hs
		63036 TFE2_HUMAN (1-654): 0: 907: 100.00		MSGN1_HUMAN (30-144): 9.73e-27: 107: 35.21
+	Hs
		63055 HTF4_HUMAN (3-654): 0: 763: 49.35		MSGN1_HUMAN (30-144): 9.73e-27: 107: 35.21
+	Hs
		63035 ITF2_HUMAN (1-654): 0: 758: 50.07		MSGN1_HUMAN (30-144): 9.73e-27: 107: 35.21