Protein: SH3G2
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)

Gene: SH3G2, SH3GL2
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q99962

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002090 - regulation of receptor internalization
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1408371

SH3G1
Endophilin-A2

8

17

Small-scale

0.971

High

1384252

SH3K1
SH3 domain-containing kinase-binding protein 1

6

20

Small-scale

0.948

High

1408389

SH3G3
Endophilin-A3

5

17

Small-scale

0.936

High

1408388

SH3G2
Endophilin-A1

3

17

Small-scale

0.867

High

1408404

CD2AP
CD2-associated protein

2

20

Small-scale

0.800

High

363777

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.729

High

1394596

ITCH
E3 ubiquitin-protein ligase Itchy homolog

4

12

Small-scale

0.706

High

1408391

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.698

High

1406471

ATX2
Ataxin-2

3

20

Small-scale

0.691

High

215946

SYNJ1
Synaptojanin-1

3

20

Small-scale

0.674

High

896872

DYN2
Dynamin-2

3

20

Small-scale

0.660

High

1356985

PDC6I
Programmed cell death 6-interacting protein

3

20

Small-scale

0.658

High

1094316

LCP2
Lymphocyte cytosolic protein 2

1

20

High-throughput

0.656

High

1154162

ITSN1
Intersectin-1

1

20

High-throughput

0.656

High

1308681

TIAM2
Rho guanine nucleotide exchange factor TIAM2

1

20

High-throughput

0.656

High

883064

AMPH
Amphiphysin

1

20

Small-scale

0.647

High

1408400

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

14

Small-scale

0.647

High

1258040

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

2

17

Small-scale

0.634

High

1234008

TNG2
Transport and Golgi organization protein 2 homolog

3

0

High-throughput

0.629

High

1050711

DYN1
Dynamin-1

2

20

Small-scale

0.619

High

212786

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

17

Small-scale

0.618

High

1209568

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

11

Small-scale

0.611

High

1017537

RHG08
Rho GTPase-activating protein 8

2

20

High-throughput

0.611

High

628644

CAP7
Azurocidin

3

4

High-throughput

0.609

High

440700

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

1105767

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

20

Small-scale

0.573

High

1105824

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.573

High

1408393

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

20

Small-scale

0.573

High

895005

EMD
Emerin

1

2

High-throughput

0.568

High

1308074

EGFL6
Epidermal growth factor-like protein 6

2

4

High-throughput

0.566

High

1380636

FBX32
F-box only protein 32

1

2

Small-scale

0.561

High

928532

TERF1
Telomeric repeat-binding factor 1

1

5

High-throughput

0.552

High

380475

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.541

High

900119

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

993310

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.541

High

1408394

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

2

High-throughput

0.541

High

651422

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.536

High

106549

APRIO
Alternative prion protein

2

7

High-throughput

0.533

High

426991

IL6
Interleukin-6

1

0

High-throughput

0.518

High

962909

NCALD
Neurocalcin-delta

1

0

High-throughput

0.513

High

1136488

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

155872

DPYL4
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.508

High

430724

TETN
Tetranectin

1

3

High-throughput

0.508

High

636883

GSTM3
Glutathione S-transferase Mu 3

1

4

High-throughput

0.508

High

1240420

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

10

High-throughput

0.508

High

1251838

PPR21
Protein phosphatase 1 regulatory subunit 21

1

1

High-throughput

0.508

High

1408396

DACT1
Dapper homolog 1

1

16

High-throughput

0.508

High

1408401

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

9

High-throughput

0.508

High

1408403

DLGP4
Disks large-associated protein 4

1

13

High-throughput

0.508

High

422981

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

416765

TYSY
Thymidylate synthase

1

0

High-throughput

0.486

High

721736

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.486

High

1249773

TM108
Transmembrane protein 108

1

0

High-throughput

0.486

High

1408392

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

20

Small-scale

0.481

High

85493

B7ZMA4
LOC553158 protein

1

20

High-throughput

0.479

High

215851

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

2

High-throughput

0.479

High

239456

AGRB2
Adhesion G protein-coupled receptor B2

1

1

Small-scale

0.479

High

464045

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

466855

ACM2
Muscarinic acetylcholine receptor M2

1

20

Small-scale

0.479

High

466956

ACM4
Muscarinic acetylcholine receptor M4

1

20

Small-scale

0.479

High

477195

ADA2A
Alpha-2A adrenergic receptor

1

20

Small-scale

0.479

High

569045

ADRB3
Beta-3 adrenergic receptor

1

7

Small-scale

0.479

High

612349

ADA2B
Alpha-2B adrenergic receptor

1

20

Small-scale

0.479

High

770814

HRH1
Histamine H1 receptor

1

20

Small-scale

0.479

High

771644

DRD3
D(3) dopamine receptor

1

19

Small-scale

0.479

High

1104253

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

5

High-throughput

0.479

High

1115956

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

Small-scale

0.479

High

1408402

DYN3
Dynamin-3

1

20

Small-scale

0.479

High

1408405

HRH3
Histamine H3 receptor

1

20

Small-scale

0.479

High

1408406

TACC3
Transforming acidic coiled-coil-containing protein 3

1

15

High-throughput

0.479

High

361718

F13A
Coagulation factor XIII A chain

1

2

High-throughput

0.464

High

1179740

ZXDC
Zinc finger protein ZXDC

1

2

High-throughput

0.464

High

1257112

PAXI1
PAX-interacting protein 1

1

16

High-throughput

0.464

High

1271211

DPPA4
Developmental pluripotency-associated protein 4

1

5

High-throughput

0.464

High

1408397

ZN219
Zinc finger protein 219

1

2

High-throughput

0.464

High

1408399

ZN580
Zinc finger protein 580

1

4

High-throughput

0.464

High

1403974

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.458

High

379567

IGHM
Immunoglobulin heavy constant mu

1

7

High-throughput

0.457

High

1059941

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

9

High-throughput

0.457

High

72897

B1AHC3
PRR5-ARHGAP8 readthrough

1

20

High-throughput

0.445

High

530287

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

176365

SYNEM
Synemin

1

20

Small-scale

0.437

High

1127116

RBM39
RNA-binding protein 39

1

10

High-throughput

0.437

High

1408395

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.437

High

1408398

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

High-throughput

0.437

High

1015293

ERH
Enhancer of rudimentary homolog

1

0

High-throughput

0.282

High

1150164

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.282

High

1408390

PRR14
Proline-rich protein 14

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025