HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TWST1 (Q15672)
Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)
Gene: TWIST1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 33961781, 10749989, 20714342, 22354994, 11248247
Identification Methods affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 654
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024