HitPredict

Interactor 1: KCRU (P12532)
Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)
Gene: CKMT1A

Interactor 2: KCRS (P17540)
Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK)
Gene: CKMT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	28514442, 33961781, 34349018, 38334954
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ATP-gua_Ptrans~ATP-gua_Ptrans, ATP-gua_Ptrans~ATP-gua_PtransN, ATP-gua_PtransN~ATP-gua_PtransN
Common GO terms	GO:0004111 - creatine kinase activity GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0046314 - phosphocreatine biosynthetic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 417 Hs			1 419
+	Mm
		718756 KCRU_MOUSE (1-417): 0: 689: 96.65		KCRS_MOUSE (1-419): 0: 707: 95.94
+	Mm
		1243157 KCRS_MOUSE (1-412): 0: 655: 79.42		KCRS_MOUSE (1-419): 0: 707: 95.94
+	Mm
		718751 KCRU_MOUSE (1-417): 0: 689: 96.65		KCRU_MOUSE (1-413): 0: 671: 80.39
+	Hs
		553108 KCRU_HUMAN (1-417): 0: 674: 100.00		KCRB_HUMAN (48-407): 0: 607: 67.04
+	Hs
		445641 KCRU_HUMAN (1-417): 0: 674: 100.00		KCRM_HUMAN (48-407): 0: 587: 65.65
+	Hs
		445643 KCRS_HUMAN (1-412): 0: 666: 80.15		KCRM_HUMAN (48-407): 0: 587: 65.65
+	Hs
		553107 KCRB_HUMAN (47-406): 0: 607: 69.81		KCRB_HUMAN (48-407): 0: 607: 67.04
+	Hs
		445640 KCRB_HUMAN (47-406): 0: 607: 69.81		KCRM_HUMAN (48-407): 0: 587: 65.65