HitPredict

Interactor 1: HMDH2 (P12684)
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA reductase 2) (EC 1.1.1.34)
Gene: HMG2

Interactor 2: HRD1 (Q08109)
ERAD-associated E3 ubiquitin-protein ligase HRD1 (EC 2.3.2.27) (HMG-CoA reductase degradation protein 1) (RING-type E3 ubiquitin transferase HRD1)
Gene: HRD1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.739

Property	Details
Experiments	11390656, 27170191, 19394298, 16270032, 20005842, 19324879
Identification Methods	cross-linking study, pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1045 Sc			1 551
+	Sc
		554379 HMDH1_YEAST (5-1034): 0: 1547: 62.38		HRD1_YEAST (1-551): 6.38e-158: 463: 100.00
+	Hs
		399704 HMDH_HUMAN (188-1035): 0: 729: 37.86		SYVN1_HUMAN (7-481): 2e-90: 291: 20.63
+	Hs
		399748 HMDH_HUMAN (188-1035): 0: 729: 37.86		AMFR_HUMAN (41-477): 2e-53: 193: 15.82
+	Hs
		399718 HMDH_HUMAN (188-1035): 0: 729: 37.86		RN139_HUMAN (148-428): 7.05e-40: 155: 15.31