HitPredict

Interactor 1: TIMP2 (P16035)
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene: TIMP2

Interactor 2: MMP15 (P51511)
Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)
Gene: MMP15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19010413
Identification Methods	protease assay
Interaction Type	enzymatic reaction

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005615 - extracellular space GO:0008270 - zinc ion binding GO:0031012 - extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 220 Hs			1 669
+	Hs
		554810 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP16_HUMAN (32-669): 0: 765: 52.35
+	Hs
		554808 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP14_HUMAN (37-669): 0: 669: 51.34
+	Hs
		838537 TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75		MMP14_HUMAN (37-669): 0: 669: 51.34
+	Hs
		726505 TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19		MMP14_HUMAN (37-669): 0: 669: 51.34
+	Hs
		344795 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP14_HUMAN (37-669): 0: 669: 51.34
+	Hs
		439263 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP3_HUMAN (30-559): 0: 565: 33.95
+	Hs
		439275 TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75		MMP3_HUMAN (30-559): 0: 565: 33.95
+	Hs
		372726 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP1_HUMAN (46-562): 0: 551: 33.14
+	Hs
		372742 TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75		MMP1_HUMAN (46-562): 0: 551: 33.14
+	Hs
		439265 TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19		MMP3_HUMAN (30-559): 0: 565: 33.95
+	Mm
		706099 TIMP3_MOUSE (10-220): 1.95e-92: 271: 43.72		MMP13_MOUSE (29-552): 0: 562: 31.91
+	Hs
		344781 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP3_HUMAN (30-559): 0: 565: 33.95
+	Hs
		344784 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP10_HUMAN (32-559): 0: 552: 32.16
+	Hs
		344777 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP1_HUMAN (46-562): 0: 551: 33.14
+	Hs
		439223 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP2_HUMAN (25-244): 2.84e-81: 272: 33.48
+	Hs
		439254 TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75		MMP2_HUMAN (25-244): 2.84e-81: 272: 33.48
+	Hs
		439230 TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19		MMP2_HUMAN (25-244): 2.84e-81: 272: 33.48
+	Hs
		540409 TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00		MMP9_HUMAN (48-244): 2.71e-62: 221: 37.06
+	Hs
		344780 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP2_HUMAN (25-244): 2.84e-81: 272: 33.48
+	Hs
		344786 TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29		MMP9_HUMAN (48-244): 2.71e-62: 221: 37.06