Protein: ODO1
2-oxoglutarate dehydrogenase complex component E1 (E1o) (HsOGDH) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase)

Gene: ODO1, OGDH
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q02218

Gene Ontology (top 5):
GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006091 - generation of precursor metabolites and energy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1035477

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

3

13

High-throughput

0.839

High

787984

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

2

14

Small-scale

0.768

High

484501

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

4

9

Small-scale

0.696

High

1035415

TCAIM
T-cell activation inhibitor, mitochondrial

1

1

High-throughput

0.691

High

470984

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

13

High-throughput

0.618

High

1035392

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.618

High

1035414

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

3

High-throughput

0.611

High

1035421

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

1

Small-scale

0.611

High

1035474

HDAC6
Protein deacetylase HDAC6

2

1

High-throughput

0.611

High

1012045

KGD4
Alpha-ketoglutarate dehydrogenase component 4

2

2

High-throughput

0.601

High

1035384

GRSF1
G-rich sequence factor 1

2

6

High-throughput

0.584

High

1035397

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

1035420

ESR2
Estrogen receptor beta

2

4

High-throughput

0.571

High

1035445

TR61B
tRNA

2

2

High-throughput

0.571

High

563642

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.552

High

395942

ESR1
Estrogen receptor

1

4

High-throughput

0.536

High

1035396

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

1035412

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.536

High

1035461

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

High-throughput

0.536

High

1035464

EXOS5
Exosome complex component RRP46

1

1

High-throughput

0.536

High

180509

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

1035405

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.515

High

843493

HD
Huntingtin

1

2

High-throughput

0.515

High

927239

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

1035454

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.513

High

1035422

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

211560

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

2

Small-scale

0.489

High

572810

NCF1
Neutrophil cytosol factor 1

1

2

High-throughput

0.489

High

1035407

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.489

High

456693

ANXA2
Annexin A2

1

1

Small-scale

0.481

High

1035439

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

Small-scale

0.481

High

61484

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.479

High

66185

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

164317

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

183632

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

241438

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

247834

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

279738

CISY
Citrate synthase, mitochondrial

1

4

High-throughput

0.479

High

281938

MPPB
Mitochondrial-processing peptidase subunit beta

1

11

High-throughput

0.479

High

287282

RF1M
Peptide chain release factor 1, mitochondrial

1

7

High-throughput

0.479

High

292117

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

350851

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

2

High-throughput

0.479

High

361632

OTC
Ornithine transcarbamylase, mitochondrial

1

2

High-throughput

0.479

High

400680

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

411763

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

413656

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

425452

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

532530

CH60
60 kDa heat shock protein, mitochondrial

1

8

High-throughput

0.479

High

606651

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

695249

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

774300

BASI
Basigin

1

1

High-throughput

0.479

High

786074

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

801273

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

828753

MDHM
Malate dehydrogenase, mitochondrial

1

7

High-throughput

0.479

High

841698

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851875

EFTS
Elongation factor Ts, mitochondrial

1

3

High-throughput

0.479

High

856247

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

862051

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

882636

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

898443

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

961966

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1024010

TFAM
Transcription factor A, mitochondrial

1

3

High-throughput

0.479

High

1028155

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

1035380

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.479

High

1035381

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

1035382

QOR
Quinone oxidoreductase

1

5

High-throughput

0.479

High

1035383

MPPA
Mitochondrial-processing peptidase subunit alpha

1

12

High-throughput

0.479

High

1035385

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.479

High

1035386

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

Small-scale

0.479

High

1035387

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1035388

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

9

High-throughput

0.479

High

1035390

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1035391

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

8

High-throughput

0.479

High

1035393

PDK1
[Pyruvate dehydrogenase

1

8

High-throughput

0.479

High

1035394

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1035398

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1035402

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.479

High

1035403

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

1035409

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

1035410

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

8

High-throughput

0.479

High

1035411

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1035418

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1035419

MCU
Calcium uniporter protein, mitochondrial

1

2

High-throughput

0.479

High

1035423

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

3

High-throughput

0.479

High

1035424

FAKD4
FAST kinase domain-containing protein 4

1

8

High-throughput

0.479

High

1035425

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

1035427

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

1035428

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1035429

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

2

High-throughput

0.479

High

1035430

RRFM
Ribosome-recycling factor, mitochondrial

1

2

High-throughput

0.479

High

1035431

MTEF3
Transcription termination factor 3, mitochondrial

1

1

High-throughput

0.479

High

1035433

AURKB
Aurora kinase B

1

2

High-throughput

0.479

High

1035436

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1035437

EFGM
Elongation factor G, mitochondrial

1

4

High-throughput

0.479

High

1035438

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1035440

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.479

High

1035441

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1035442

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

1035443

MTG1
Mitochondrial ribosome-associated GTPase 1

1

2

High-throughput

0.479

High

1035446

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

1035447

RT26
Small ribosomal subunit protein mS26

1

2

High-throughput

0.479

High

1035450

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

8

High-throughput

0.479

High

1035451

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

1035452

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

1035453

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1035456

MTRFR
Mitochondrial translation release factor in rescue

1

7

High-throughput

0.479

High

1035457

MTG2
Mitochondrial ribosome-associated GTPase 2

1

6

High-throughput

0.479

High

1035458

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1035459

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

6

High-throughput

0.479

High

1035460

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.479

High

1035462

NGRN
Neugrin

1

1

High-throughput

0.479

High

1035467

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.479

High

1035468

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

1035469

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

2

High-throughput

0.479

High

1035472

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

8

High-throughput

0.479

High

1035473

MRES1
Mitochondrial transcription rescue factor 1

1

2

High-throughput

0.479

High

1035475

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

7

High-throughput

0.479

High

1035476

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1035478

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.479

High

1035479

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.479

High

1035480

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

1035413

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.470

High

536998

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

588499

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

597326

PDE6A
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

1

0

High-throughput

0.458

High

799007

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

869022

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

904616

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

926951

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

1035401

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1035404

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1035408

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1035426

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1035434

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1035444

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1035470

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1035471

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

653259

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

931501

RD23A
UV excision repair protein RAD23 homolog A

1

1

High-throughput

0.445

High

934484

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

939180

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.445

High

1035389

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

1035400

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

1035481

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

105780

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

353262

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

464689

CXB1
Gap junction beta-1 protein

1

2

Small-scale

0.437

High

650133

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.437

High

767991

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1015376

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.437

High

1035406

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1035416

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

1035449

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.437

High

1035455

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.437

High

1035465

ANLN
Anillin

1

1

High-throughput

0.437

High

1035435

MCEE
Methylmalonyl-CoA epimerase, mitochondrial

1

0

High-throughput

0.426

High

324115

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.407

High

841161

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

1035399

CP135
Centrosomal protein of 135 kDa

1

7

High-throughput

0.407

High

1035417

POC5
Centrosomal protein POC5

1

1

High-throughput

0.407

High

866648

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

1035432

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

370187

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

1035463

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1035395

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low

1035448

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

1035466

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025