HitPredict

Interactor 1: CREB1 (P16220)
Cyclic AMP-responsive element-binding protein 1 (CREB-1) (cAMP-responsive element-binding protein 1)
Gene: CREB1

Interactor 2: FHL2 (Q14192)
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Gene: FHL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	11046156
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 327 Hs			1 279
+	Hs
		556862 CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00		FHL3_HUMAN (66-279): 2.11e-40: 143: 27.32
+	Hs
		556888 CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00		FHL5_HUMAN (65-279): 3.56e-38: 137: 31.34
+	Hs
		532299 CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00		ZNF35_HUMAN (93-277): 2.24e-35: 134: 15.39
+	Hs
		556965 CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00		ZN436_HUMAN (110-277): 1.1e-34: 131: 14.61
+	Hs
		556910 CREB1_HUMAN (1-327): 6.86e-146: 415: 100.00		ZN677_HUMAN (6-161): 2.45e-31: 123: 12.82
+	Hs
		974395 CREM_HUMAN (1-327): 1.82e-133: 385: 60.52		FHL5_HUMAN (65-279): 3.56e-38: 137: 31.34
+	Hs
		579141 ATF1_HUMAN (72-326): 2.98e-94: 282: 65.13		FHL2_HUMAN (1-279): 4.64e-77: 237: 100.00
+	Mm
		653083 CREM_MOUSE (1-327): 2.11e-133: 385: 62.61		FHL5_MOUSE (3-92): 1.93e-12: 67.6: 33.70