HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	8943348, 35384245, 21596750
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 217
+	Hs
		452385 PGFRB_HUMAN (29-1089): 0: 650: 43.33		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Rn
		595729 PGFRA_RAT (7-1089): 0: 811: 91.04		LYN_RAT (129-215): 4.14e-11: 63.4: 23.60
+	Hs
		452495 PGFRB_HUMAN (29-1089): 0: 650: 43.33		VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00
+	Mm
		403541 KIT_MOUSE (18-994): 0: 571: 33.43		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		452344 PGFRB_HUMAN (29-1089): 0: 650: 43.33		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337317 PGFRB_HUMAN (29-1089): 0: 650: 43.33		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		452370 PGFRB_HUMAN (29-1089): 0: 650: 43.33		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		452342 PGFRB_HUMAN (29-1089): 0: 650: 43.33		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		411953 PGFRB_HUMAN (29-1089): 0: 650: 43.33		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433221 PGFRB_HUMAN (29-1089): 0: 650: 43.33		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		452338 PGFRB_HUMAN (29-1089): 0: 650: 43.33		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		452375 PGFRB_HUMAN (29-1089): 0: 650: 43.33		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Hs
		411567 KIT_HUMAN (18-978): 0: 559: 33.64		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		337322 KIT_HUMAN (18-978): 0: 559: 33.64		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		403536 KIT_MOUSE (18-994): 0: 571: 33.43		VAV_MOUSE (2-60): 8.53e-15: 74.6: 42.37
+	Mm
		292679 KIT_MOUSE (18-994): 0: 571: 33.43		GRAP2_MOUSE (3-55): 1.57e-10: 61.5: 37.74
+	Hs
		411962 KIT_HUMAN (18-978): 0: 559: 33.64		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433226 KIT_HUMAN (18-978): 0: 559: 33.64		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433539 KIT_HUMAN (18-978): 0: 559: 33.64		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		275165 KIT_HUMAN (18-978): 0: 559: 33.64		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62