HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1342
+	Hs
		433253 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		147371 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383538 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338763 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		147370 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337789 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		147369 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		147378 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		147424 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK2_HUMAN (673-1201): 9.77e-104: 355: 25.96
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		147402 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		TXK_HUMAN (707-969): 2.69e-44: 171: 37.12
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (713-992): 3.48e-41: 167: 32.19
+	Hs
		147414 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19
+	Hs
		146667 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		147373 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Mm
		193373 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		INSR_MOUSE (329-650): 4.73e-21: 102: 16.98