HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: FCG2C (P31995)
Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32)
Gene: FCGR2C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 323
+	Hs
		557632 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		DCC_HUMAN (26-323): 4.23e-45: 166: 11.52
+	Dm
		219806 NCK_DROME (5-374): 5.6e-68: 225: 42.54		O44924_DROME (2-323): 5.29e-52: 186: 12.47
+	Hs
		209143 NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24		FCRL2_HUMAN (28-299): 1.48e-26: 111: 17.00
+	Hs
		557621 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36
+	Hs
		557704 NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00		MYLK_HUMAN (236-313): 1.1e-09: 61.7: 11.11
+	Hs
		412048 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FCG2C_HUMAN (1-323): 2.58e-76: 238: 100.00
+	Hs
		522812 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCG2C_HUMAN (1-323): 2.58e-76: 238: 100.00
+	Hs
		519366 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		FCG2A_HUMAN (38-323): 1.1e-60: 198: 91.70
+	Hs
		519376 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		FCG2A_HUMAN (38-323): 1.1e-60: 198: 91.70
+	Hs
		590600 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		CD22_HUMAN (40-242): 3.64e-43: 160: 22.75
+	Hs
		590607 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		CD22_HUMAN (40-242): 3.64e-43: 160: 22.75
+	Mm
		643060 P85A_MOUSE (241-376): 1.59e-22: 101: 19.57		CD22_MOUSE (3-275): 6.66e-17: 83.4: 16.09
+	Hs
		412047 FYN_HUMAN (7-173): 7.47e-21: 96: 15.39		FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36
+	Mm
		722901 GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03		CD22_MOUSE (3-275): 6.66e-17: 83.4: 16.09
+	Hs
		655385 P85A_HUMAN (241-376): 1.37e-22: 101: 19.57		MYLK_HUMAN (236-313): 1.1e-09: 61.7: 11.11
+	Hs
		442771 HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24		FCGR1_HUMAN (133-313): 1.19e-10: 63.7: 14.92
+	Hs
		522811 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36
+	Hs
		685205 GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81		FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36
+	Hs
		519400 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		FCERA_HUMAN (126-313): 2.14e-12: 67.9: 17.37
+	Hs
		523003 SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32		MYLK_HUMAN (236-313): 1.1e-09: 61.7: 11.11