HitPredict

Interactor 1: LAMP2 (P13473)
Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Gene: LAMP2

Interactor 2: RHEB (Q15382)
GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain)
Gene: RHEB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	28514442, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 410 Hs			1 184
+	Hs
		561982 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB1A_HUMAN (4-183): 1.16e-77: 232: 30.27
+	Hs
		561957 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB13_HUMAN (1-180): 8.57e-77: 229: 28.42
+	Hs
		561981 LAMP2_HUMAN (1-410): 0: 557: 100.00		RB11A_HUMAN (4-180): 2.65e-76: 229: 29.78
+	Hs
		562382 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB1B_HUMAN (4-173): 8.8e-77: 229: 30.41
+	Hs
		561974 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB2A_HUMAN (1-173): 3.7e-75: 226: 31.03
+	Hs
		562265 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAB2B_HUMAN (1-173): 6.7e-74: 223: 29.89
+	Hs
		561983 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAP1A_HUMAN (5-163): 2.21e-36: 126: 40.85
+	Hs
		540390 LAMP1_HUMAN (26-410): 3.77e-155: 446: 34.43		RAB1A_HUMAN (4-183): 1.16e-77: 232: 30.27
+	Hs
		540366 LAMP1_HUMAN (26-410): 3.77e-155: 446: 34.43		RAB13_HUMAN (1-180): 8.57e-77: 229: 28.42
+	Hs
		540389 LAMP1_HUMAN (26-410): 3.77e-155: 446: 34.43		RB11A_HUMAN (4-180): 2.65e-76: 229: 29.78
+	Hs
		540665 LAMP1_HUMAN (26-410): 3.77e-155: 446: 34.43		RAB1B_HUMAN (4-173): 8.8e-77: 229: 30.41
+	Hs
		540384 LAMP1_HUMAN (26-410): 3.77e-155: 446: 34.43		RAB2A_HUMAN (1-173): 3.7e-75: 226: 31.03
+	Hs
		539765 LAMP2_HUMAN (1-410): 0: 557: 100.00		RALA_HUMAN (8-171): 2.89e-31: 114: 35.54
+	Hs
		518578 LAMP2_HUMAN (1-410): 0: 557: 100.00		RAP2A_HUMAN (19-183): 6.73e-30: 109: 38.24
+	Hs
		981383 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RAB1A_HUMAN (4-183): 1.16e-77: 232: 30.27
+	Hs
		1430491 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RAB1B_HUMAN (4-173): 8.8e-77: 229: 30.41
+	Hs
		902235 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RAB13_HUMAN (1-180): 8.57e-77: 229: 28.42
+	Hs
		976672 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RB11A_HUMAN (4-180): 2.65e-76: 229: 29.78
+	Hs
		956545 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RAB2A_HUMAN (1-173): 3.7e-75: 226: 31.03
+	Hs
		518636 LAMP3_HUMAN (155-410): 7.3e-75: 240: 25.95		RAP2A_HUMAN (19-183): 6.73e-30: 109: 38.24