HitPredict

Interactor 1: IL7RA (P16871)
Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)
Gene: IL7R

Interactor 2: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

The method score is based on:

Property	Details
Experiments	8266077, 20167604, 23726671
Identification Methods	anti tag coimmunoprecipitation, proximity ligation assay
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004896 - cytokine receptor activity GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006955 - immune response and 7 others more... GO:0007165 - signal transduction GO:0009897 - external side of plasma membrane GO:0010467 - gene expression GO:0010628 - positive regulation of gene expression GO:0019221 - cytokine-mediated signaling pathway GO:0033077 - T cell differentiation in thymus GO:0033089 - positive regulation of T cell differentiation in thymus
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	459
Hs

1	369

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024