HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CXL17 (Q6UXB2)
C-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
Gene: CXCL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0010759 - positive regulation of macrophage chemotaxis GO:0048246 - macrophage chemotaxis GO:0090026 - positive regulation of monocyte chemotaxis
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 91 Hs			1 119
+	Hs
		1249698 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		1009599 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		562851 CCL2_HUMAN (1-90): 2.18e-27: 97.3: 33.70		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		1249701 CCL26_HUMAN (21-89): 8.12e-25: 90.8: 40.58		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		1249697 CCL17_HUMAN (1-89): 3.42e-23: 86.5: 28.09		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		869318 XCL1_HUMAN (1-90): 3.93e-22: 84.2: 33.33		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		1249700 XCL2_HUMAN (1-90): 7.49e-22: 83.8: 33.33		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		190738 CCL25_HUMAN (8-89): 5.81e-19: 77.3: 28.89		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		141763 CCL21_HUMAN (23-91): 1.25e-18: 76.1: 28.77		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00
+	Hs
		1008605 CCL20_HUMAN (3-90): 5.29e-18: 73.4: 28.89		CXL17_HUMAN (1-119): 5.23e-77: 224: 100.00