HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 776
+	Hs
		777455 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL1_HUMAN (1-776): 0: 909: 100.00
+	Hs
		777458 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL4A_HUMAN (7-776): 0: 778: 30.41
+	Hs
		777459 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL4B_HUMAN (7-776): 0: 771: 29.90
+	Hs
		777457 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL3_HUMAN (9-776): 0: 746: 30.47
+	Hs
		341765 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL1_HUMAN (1-776): 0: 909: 100.00
+	Hs
		777456 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL2_HUMAN (13-776): 0: 718: 35.98
+	Hs
		437163 K2C8_HUMAN (140-516): 9.22e-163: 474: 69.23		CUL3_HUMAN (9-776): 0: 746: 30.47
+	Hs
		407285 K2C6B_HUMAN (2-505): 1.51e-89: 289: 79.56		CUL1_HUMAN (1-776): 0: 909: 100.00
+	Hs
		551580 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		CUL5_HUMAN (2-776): 0: 620: 28.85
+	Hs
		777531 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		CUL5_HUMAN (2-776): 0: 620: 28.85
+	Hs
		341768 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL4A_HUMAN (7-776): 0: 778: 30.41
+	Hs
		341769 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL4B_HUMAN (7-776): 0: 771: 29.90
+	Hs
		566372 K2C5_HUMAN (1-590): 1.3e-98: 313: 100.00		CUL4B_HUMAN (7-776): 0: 771: 29.90
+	Hs
		1114411 KRT84_HUMAN (1-569): 3.5e-104: 328: 50.96		CUL3_HUMAN (9-776): 0: 746: 30.47
+	Hs
		341767 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL3_HUMAN (9-776): 0: 746: 30.47
+	Hs
		566371 K2C5_HUMAN (1-590): 1.3e-98: 313: 100.00		CUL3_HUMAN (9-776): 0: 746: 30.47
+	Hs
		341766 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL2_HUMAN (13-776): 0: 718: 35.98
+	Hs
		566370 K2C5_HUMAN (1-590): 1.3e-98: 313: 100.00		CUL2_HUMAN (13-776): 0: 718: 35.98
+	Hs
		341828 K2C75_HUMAN (1-567): 1.14e-102: 323: 70.02		CUL5_HUMAN (2-776): 0: 620: 28.85
+	Hs
		566432 K2C5_HUMAN (1-590): 1.3e-98: 313: 100.00		CUL5_HUMAN (2-776): 0: 620: 28.85