Protein: K2C3
Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3)

Gene: K2C3, KRT3
Organism: Homo sapiens
Interactions: 93
UniProt ID: P12035

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0030280 - structural constituent of skin epidermis
GO:0030855 - epithelial cell differentiation
GO:0031424 - keratinization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341729

K2C75
Keratin, type II cytoskeletal 75

3

20

High-throughput

0.843

High

475506

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

476258

K1C16
Keratin, type I cytoskeletal 16

3

20

High-throughput

0.843

High

551539

K1C20
Keratin, type I cytoskeletal 20

3

20

High-throughput

0.843

High

300291

KRT34
Keratin, type I cuticular Ha4

2

20

High-throughput

0.783

High

300547

KRT36
Keratin, type I cuticular Ha6

2

20

High-throughput

0.783

High

300622

KRT37
Keratin, type I cuticular Ha7

2

20

High-throughput

0.783

High

300721

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.783

High

385045

K1C14
Keratin, type I cytoskeletal 14

2

20

High-throughput

0.783

High

551554

KT33B
Keratin, type I cuticular Ha3-II

2

20

High-throughput

0.783

High

551557

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.783

High

551558

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

551566

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.783

High

551568

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

551569

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

551570

K1C26
Keratin, type I cytoskeletal 26

2

20

High-throughput

0.783

High

551571

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

551578

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

551531

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.621

High

551535

K1C15
Keratin, type I cytoskeletal 15

1

20

High-throughput

0.621

High

551555

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

551565

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.621

High

385226

K2C6A
Keratin, type II cytoskeletal 6A

1

19

High-throughput

0.618

High

436777

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.618

High

437069

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

474434

VIME
Vimentin

1

20

High-throughput

0.618

High

551532

K2C5
Keratin, type II cytoskeletal 5

1

19

High-throughput

0.618

High

551534

DESM
Desmin

1

20

High-throughput

0.618

High

551541

PERI
Peripherin

1

20

High-throughput

0.618

High

551586

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

551596

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

169414

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

5

High-throughput

0.606

High

551533

TRI27
Zinc finger protein RFP

2

9

High-throughput

0.606

High

551552

TRAF1
TNF receptor-associated factor 1

2

10

High-throughput

0.606

High

551561

KR132
Keratin-associated protein 13-2

2

1

High-throughput

0.606

High

551562

PKHG4
Puratrophin-1

2

2

High-throughput

0.606

High

551582

HAUS1
HAUS augmin-like complex subunit 1

2

1

High-throughput

0.606

High

551585

SPAG5
Sperm-associated antigen 5

2

13

High-throughput

0.606

High

551589

KIFC3
Kinesin-like protein KIFC3

2

8

High-throughput

0.606

High

551597

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

551572

SAPC2
Suppressor APC domain-containing protein 2

2

0

High-throughput

0.580

High

551584

LURA1
Leucine rich adaptor protein 1

2

0

High-throughput

0.580

High

217046

MS18B
Protein Mis18-beta

2

5

High-throughput

0.553

High

551540

NUP62
Nuclear pore glycoprotein p62

2

5

High-throughput

0.553

High

551548

DEUP1
Deuterosome assembly protein 1

2

8

High-throughput

0.553

High

551588

ZN426
Zinc finger protein 426

2

2

High-throughput

0.553

High

551591

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.553

High

551598

LHX3
LIM/homeobox protein Lhx3

2

5

High-throughput

0.553

High

551544

EPIPL
Epiplakin

1

20

High-throughput

0.536

High

551579

CSN5
COP9 signalosome complex subunit 5

1

16

High-throughput

0.536

High

551580

CUL5
Cullin-5

1

20

High-throughput

0.536

High

551550

FP100
Fanconi anemia core complex-associated protein 100

1

0

High-throughput

0.513

High

551574

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.513

High

69352

WASH1
WASH complex subunit 1

1

2

High-throughput

0.481

High

187270

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

8

High-throughput

0.479

High

302350

RNF8
E3 ubiquitin-protein ligase RNF8

1

13

High-throughput

0.479

High

362674

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

387218

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.479

High

519693

ANDR
Androgen receptor

1

11

High-throughput

0.479

High

551536

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

551538

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

551542

EPS15
Epidermal growth factor receptor substrate 15

1

11

High-throughput

0.479

High

551543

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

551545

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

551547

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

551553

DCTN1
Dynactin subunit 1

1

16

High-throughput

0.479

High

551560

LARP7
La-related protein 7

1

10

High-throughput

0.479

High

551564

OTU1
Ubiquitin thioesterase OTU1

1

7

High-throughput

0.479

High

551576

NHLC2
NHL repeat-containing protein 2

1

5

High-throughput

0.479

High

551581

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

6

Small-scale

0.479

High

551583

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

551590

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

9

High-throughput

0.479

High

551593

RN208
RING finger protein 208

1

20

Small-scale

0.479

High

551595

ANLN
Anillin

1

10

High-throughput

0.479

High

551600

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

109168

G4XUV3
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.470

High

551577

CC197
Uncharacterized protein CCDC197

1

1

High-throughput

0.470

High

551546

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

551549

LG3BP
Galectin-3-binding protein

1

7

High-throughput

0.445

High

551592

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

551563

HYI
Putative hydroxypyruvate isomerase

1

1

High-throughput

0.439

High

293126

CD123
Translation initiation factor eIF2 assembly protein

1

7

High-throughput

0.437

High

324472

HEXI1
Protein HEXIM1

1

16

High-throughput

0.437

High

551551

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.437

High

551556

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

High-throughput

0.437

High

551559

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

3

Small-scale

0.437

High

551575

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

Small-scale

0.437

High

551599

PHTF1
Protein PHTF1

1

9

High-throughput

0.437

High

551537

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

551573

SULF2
Extracellular sulfatase Sulf-2

1

8

High-throughput

0.407

High

551587

SLX1
Structure-specific endonuclease subunit SLX1

1

2

High-throughput

0.407

High

551567

CC062
Uncharacterized protein C3orf62

2

0

High-throughput

0.316

High

551594

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025