HitPredict

Interactor 1: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Interactor 2: CXA8 (P48165)
Gap junction alpha-8 protein (Connexin-50) (Cx50) (Lens fiber protein MP70)
Gene: GJA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Connexin~Connexin
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005243 - gap junction channel activity GO:0005886 - plasma membrane GO:0005922 - connexin complex GO:0007267 - cell-cell signaling
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 433
+	Hs
		567354 CXA1_HUMAN (1-382): 0: 545: 100.00		CXA3_HUMAN (1-433): 0: 535: 44.37
+	Hs
		566948 CXA1_HUMAN (1-382): 0: 545: 100.00		CXA5_HUMAN (1-433): 8.65e-164: 466: 43.45
+	Rn
		435207 CXA1_RAT (1-382): 0: 546: 97.64		CXA1_RAT (1-343): 9.46e-123: 363: 39.77
+	Hs
		566913 CXA1_HUMAN (1-382): 0: 545: 100.00		CXA1_HUMAN (1-343): 1.53e-122: 362: 39.48
+	Rn
		435243 CXA1_RAT (1-382): 0: 546: 97.64		CXB2_RAT (3-240): 5.35e-123: 357: 51.46
+	Hs
		566949 CXA1_HUMAN (1-382): 0: 545: 100.00		CXG1_HUMAN (4-366): 2.43e-117: 349: 32.23
+	Mm
		613301 CXA1_MOUSE (1-382): 0: 544: 97.38		CXG1_MOUSE (4-259): 1.91e-115: 345: 39.72
+	Mm
		613302 CXA1_MOUSE (1-382): 0: 544: 97.38		CXB3_MOUSE (3-238): 2.46e-110: 327: 39.92
+	Hs
		567163 CXA1_HUMAN (1-382): 0: 545: 100.00		CXD3_HUMAN (1-238): 1.26e-95: 290: 40.34
+	Hs
		661197 CXA3_HUMAN (1-382): 1.9e-152: 438: 39.82		CXB2_HUMAN (3-240): 4.54e-123: 358: 51.46
+	Hs
		734430 CXA3_HUMAN (1-382): 1.9e-152: 438: 39.82		CXG1_HUMAN (4-366): 2.43e-117: 349: 32.23
+	Hs
		661148 CXA5_HUMAN (1-382): 2.28e-140: 405: 40.40		CXB2_HUMAN (3-240): 4.54e-123: 358: 51.46
+	Hs
		661149 CXA8_HUMAN (1-382): 1.55e-135: 395: 37.81		CXB2_HUMAN (3-240): 4.54e-123: 358: 51.46
+	Hs
		274164 CXA3_HUMAN (1-382): 1.9e-152: 438: 39.82		CXB3_HUMAN (3-238): 8.81e-105: 313: 40.34
+	Hs
		734419 CXG1_HUMAN (4-373): 1.81e-130: 381: 32.49		CXD3_HUMAN (1-238): 1.26e-95: 290: 40.34