HitPredict

Interactor 1: CAP (P17555)
Adenylyl cyclase-associated protein (CAP)
Gene: SRV2

Interactor 2: COFI (Q03048)
Cofilin (Actin-depolymerizing factor 1)
Gene: COF1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	11805837, 16554755
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007015 - actin filament organization GO:0030042 - actin filament depolymerization GO:0030479 - actin cortical patch GO:0051014 - actin filament severing
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 526 Sc			1 143
+	Hs
		618057 CAP1_HUMAN (12-526): 0: 630: 32.56		COF1_HUMAN (3-140): 2.11e-46: 149: 35.44
+	Hs
		618009 CAP2_HUMAN (12-524): 0: 619: 34.63		COF1_HUMAN (3-140): 2.11e-46: 149: 35.44
+	Hs
		768477 CAP2_HUMAN (12-524): 0: 619: 34.63		Q549N0_HUMAN (3-138): 7.4e-46: 148: 34.62
+	Hs
		768490 CAP2_HUMAN (12-524): 0: 619: 34.63		COF2_HUMAN (3-138): 7.4e-46: 148: 34.62
+	Hs
		965198 CAP1_HUMAN (12-526): 0: 630: 32.56		TWF2_HUMAN (4-141): 6.01e-36: 128: 22.38
+	Hs
		965184 CAP1_HUMAN (12-526): 0: 630: 32.56		TWF1_HUMAN (4-136): 7.3e-35: 125: 22.86
+	Hs
		768480 CAP2_HUMAN (12-524): 0: 619: 34.63		TWF2_HUMAN (4-141): 6.01e-36: 128: 22.38
+	Hs
		768472 CAP2_HUMAN (12-524): 0: 619: 34.63		TWF1_HUMAN (4-136): 7.3e-35: 125: 22.86
+	Sp
		737042 CAP_SCHPO (10-524): 0: 576: 33.09		COFI_SCHPO (1-138): 5.01e-53: 165: 60.87