Protein: Q9VKW5
Prolyl endopeptidase (EC 3.4.21.-)

Gene: Q9VKW5, DmelCG5355
Organism: Drosophila melanogaster
Interactions: 203
UniProt ID: Q9VKW5

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0017171 - serine hydrolase activity
GO:0070012 - oligopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1262864

Q7JX87
1-Cys peroxiredoxin

2

4

High-throughput

0.571

High

1476871

Q9VHX4
LD24679p

2

4

High-throughput

0.571

High

1479928

Q9VTY2
Uncharacterized protein, isoform A

2

4

High-throughput

0.571

High

1306147

Q8IRD3
Glutathione peroxidase

2

0

High-throughput

0.547

High

197856

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

2

1

High-throughput

0.521

High

649111

ANX10
Annexin B10

2

1

High-throughput

0.521

High

1464347

Q9V3V2
peptidylprolyl isomerase

2

4

High-throughput

0.521

High

1474757

Q9VGK3
peptidylprolyl isomerase

2

4

High-throughput

0.521

High

1479927

Q9VSL2
Glutathione S transferase O3

2

1

High-throughput

0.521

High

1479953

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

3

High-throughput

0.521

High

1306698

Q8IRS7
Ciboulot, isoform C

1

1

High-throughput

0.479

High

1474855

Q9VGM2
Fatty acid-binding protein, muscle

1

1

High-throughput

0.479

High

1479933

PYRG
CTP synthase

1

0

High-throughput

0.458

High

47799

A0AQH0
Proteasome subunit beta

1

2

High-throughput

0.445

High

54077

A1Z892
1-Cys peroxiredoxin

1

4

High-throughput

0.445

High

121311

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.445

High

357364

O97428
Ciboulot, isoform A

1

1

High-throughput

0.445

High

458127

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.445

High

556764

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.445

High

611531

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.445

High

614276

SGG
Protein kinase shaggy

1

1

High-throughput

0.445

High

652786

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.445

High

726450

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

821912

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.445

High

822088

PSB1
Proteasome subunit beta type-1

1

4

High-throughput

0.445

High

856114

MOEH
Moesin/ezrin/radixin homolog 1

1

1

High-throughput

0.445

High

871684

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

4

High-throughput

0.445

High

874708

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.445

High

1019658

TRXR1
Thioredoxin reductase 1, mitochondrial

1

1

High-throughput

0.445

High

1019917

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.445

High

1176741

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.445

High

1262171

Q7JVH6
LD24696p

1

4

High-throughput

0.445

High

1264144

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

1264718

Q7K148
Proteasome subunit beta

1

2

High-throughput

0.445

High

1268099

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.445

High

1303959

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.445

High

1305761

Q8IQZ7
FI19014p1

1

4

High-throughput

0.445

High

1464125

Q9V3Q4
thioredoxin-dependent peroxiredoxin

1

4

High-throughput

0.445

High

1465045

THIO2
Thioredoxin-2

1

5

High-throughput

0.445

High

1466075

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.445

High

1472918

FLNA
Filamin-A

1

4

High-throughput

0.445

High

1475935

TEBPH
Cytosolic Prostaglandin E synthase

1

1

High-throughput

0.445

High

1476466

Q9VHN7
transketolase

1

1

High-throughput

0.445

High

1476621

DPP3
Dipeptidyl peptidase 3

1

1

High-throughput

0.445

High

1478486

Q9VJJ0
Proteasome subunit beta

1

3

High-throughput

0.445

High

1479905

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

2

High-throughput

0.445

High

1479906

EF1D
Probable elongation factor 1-delta

1

1

High-throughput

0.445

High

1479915

PSB4
Proteasome subunit beta type-4

1

7

High-throughput

0.445

High

1479922

Q9VQL1
serine--tRNA ligase

1

1

High-throughput

0.445

High

1479924

Q9VRL1
GEO06356p1

1

1

High-throughput

0.445

High

1479931

Q9VUC1
Hsc70Cb, isoform A

1

2

High-throughput

0.445

High

1479944

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

1479949

Q9W0E4
Aminopeptidase

1

1

High-throughput

0.445

High

1479959

WUHO
tRNA

1

3

High-throughput

0.445

High

1479961

Q9W478
RE43153p

1

1

High-throughput

0.445

High

1479963

PSB3
Proteasome subunit beta type-3

1

4

High-throughput

0.445

High

1479966

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.445

High

1479968

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.445

High

1070927

Q0KI67
Myosin heavy chain-like, isoform G

1

3

High-throughput

0.439

High

460151

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

578149

ENO
Enolase

1

0

High-throughput

0.426

High

835195

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

929039

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.426

High

1031259

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

1176816

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.426

High

1260872

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

1266206

Q7K3Z3
GH01724p

1

0

High-throughput

0.426

High

1267958

TERA
Transitional endoplasmic reticulum ATPase TER94

1

0

High-throughput

0.426

High

1321717

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

1440060

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

1440597

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

1463337

Q9V3D8
GH27579p

1

0

High-throughput

0.426

High

1466269

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.426

High

1467644

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

1468197

Q9VAN7
Phosphoglycerate mutase

1

0

High-throughput

0.426

High

1470520

Q9VCK6
LD34157p

1

0

High-throughput

0.426

High

1470983

Q9VD02
GH14779p

1

0

High-throughput

0.426

High

1474295

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

1475660

Q9VH81
protein-serine/threonine phosphatase

1

0

High-throughput

0.426

High

1477367

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.426

High

1477563

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

1479910

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.426

High

1479911

AK200
A-kinase anchor protein 200

1

0

High-throughput

0.426

High

1479913

Q9VMU6
LD31822p

1

0

High-throughput

0.426

High

1479926

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

1479938

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.426

High

1479943

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.426

High

1479951

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

1479952

TALDO
Probable transaldolase

1

0

High-throughput

0.426

High

1479955

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.426

High

1303785

Q8INC3
Myosin heavy chain-like, isoform B

1

3

High-throughput

0.417

High

57635

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.407

High

234616

VINC
Vinculin

1

2

High-throughput

0.407

High

234779

O46067
Hypoxia up-regulated protein 1

1

3

High-throughput

0.407

High

356429

O97102
Small ubiquitin-related modifier

1

1

High-throughput

0.407

High

609467

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.407

High

614947

SYB
Synaptobrevin

1

2

High-throughput

0.407

High

648945

ANXB9
Annexin B9

1

1

High-throughput

0.407

High

712411

CALR
Calreticulin

1

4

High-throughput

0.407

High

762624

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.407

High

929562

PDI
Protein disulfide-isomerase

1

8

High-throughput

0.407

High

1052276

HMGD
High mobility group protein D

1

1

High-throughput

0.407

High

1052474

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.407

High

1176336

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.407

High

1176600

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.407

High

1191706

Q3YMU0
Protein disulfide-isomerase

1

8

High-throughput

0.407

High

1261561

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.407

High

1263049

Q7JXC4
CG6459 protein

1

1

High-throughput

0.407

High

1269490

Q7KTW5
Inositol-1-monophosphatase

1

1

High-throughput

0.407

High

1321988

Q8MYY7
RE44624p

1

2

High-throughput

0.407

High

1343047

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

1

High-throughput

0.407

High

1343343

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.407

High

1344449

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.407

High

1374796

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

1377682

FAXC
Failed axon connections

1

1

High-throughput

0.407

High

1465272

PDIA6
Protein disulfide-isomerase A6 homolog

1

9

High-throughput

0.407

High

1466494

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

2

High-throughput

0.407

High

1467738

Q9VAC4
GEO09167p1

1

1

High-throughput

0.407

High

1468650

Q9VAY2
Heat shock protein 83

1

2

High-throughput

0.407

High

1469528

Q9VBR6
RE74917p

1

1

High-throughput

0.407

High

1471151

Q9VD29
small monomeric GTPase

1

3

High-throughput

0.407

High

1472471

Q9VEB1
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

1473815

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.407

High

1478351

Q9VJD4
LD24721p

1

1

High-throughput

0.407

High

1479907

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

4

High-throughput

0.407

High

1479908

Q9VL70
HL08109p

1

1

High-throughput

0.407

High

1479909

FKB59
FK506-binding protein 59

1

3

High-throughput

0.407

High

1479912

SYAC
Alanine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.407

High

1479918

Q9VPN5
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.407

High

1479920

Q9VQ61
Aspartate aminotransferase

1

2

High-throughput

0.407

High

1479930

WDR1
Actin-interacting protein 1

1

1

High-throughput

0.407

High

1479935

Q9VVC5
2-oxoglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

1479936

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.407

High

1479937

Q9VVL7
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.407

High

1479941

Q9VWQ7
Coactosin-like protein

1

1

High-throughput

0.407

High

1479942

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.407

High

1479945

TXND5
Thioredoxin domain-containing protein 5 homolog

1

9

High-throughput

0.407

High

1479946

Q9VZI1
Transgelin

1

1

High-throughput

0.407

High

1479948

Q9W022
GEO01508p1

1

7

High-throughput

0.407

High

1479950

Q9W0H8
Reticulocalbin-3

1

2

High-throughput

0.407

High

1479958

CISY
Probable citrate synthase, mitochondrial

1

2

High-throughput

0.407

High

1479960

Q9W457
Serine hydroxymethyltransferase

1

2

High-throughput

0.407

High

1479964

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.407

High

357590

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.298

High

477022

NDKA
Nucleoside diphosphate kinase

2

0

High-throughput

0.298

High

1445436

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

0

High-throughput

0.298

High

304571

ARI2
Potential E3 ubiquitin-protein ligase ariadne-2

1

0

High-throughput

0.265

Low

1267326

APAF
Apoptosome protein Dark

1

0

High-throughput

0.238

Low

57858

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

86565

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

145987

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.232

Low

195116

O16043
Anon1A4

1

0

High-throughput

0.232

Low

304702

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

305258

TRMB
tRNA

1

0

High-throughput

0.232

Low

305717

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.232

Low

356576

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.232

Low

426784

HP1
Heterochromatin protein 1

1

0

High-throughput

0.232

Low

561829

MODU
DNA-binding protein modulo

1

0

High-throughput

0.232

Low

632994

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.232

Low

682816

PROF
Profilin

1

0

High-throughput

0.232

Low

925842

SET
Protein SET

1

0

High-throughput

0.232

Low

930210

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1026659

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

1070813

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

1262681

Q7JWV7
Tetraspanin

1

0

High-throughput

0.232

Low

1265300

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1265841

Q7K3J0
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

1266816

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

1267267

Q7KKI0
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.232

Low

1268283

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.232

Low

1345281

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.232

Low

1374575

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.232

Low

1374700

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

1427873

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.232

Low

1440169

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

1445637

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1463684

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

1464518

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.232

Low

1464599

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

1466982

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

1469605

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1474351

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1475124

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.232

Low

1479299

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.232

Low

1479914

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.232

Low

1479916

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

1479917

Q9VP52
GH24315p

1

0

High-throughput

0.232

Low

1479919

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

1479921

BACC
Bacchus

1

0

High-throughput

0.232

Low

1479923

Q9VRD6
NTF2-related export protein

1

0

High-throughput

0.232

Low

1479925

Q9VRP2
Uncharacterized protein, isoform A

1

0

High-throughput

0.232

Low

1479929

Q9VU35
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.232

Low

1479932

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.232

Low

1479934

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

1479939

Q9VW70
FI21813p1

1

0

High-throughput

0.232

Low

1479940

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

1479947

Q9VZY0
LD45195p

1

0

High-throughput

0.232

Low

1479954

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.232

Low

1479956

Q9W3X6
fumarate hydratase

1

0

High-throughput

0.232

Low

1479957

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1479962

NSUN2
tRNA

1

0

High-throughput

0.232

Low

1479965

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.232

Low

1479967

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025