Protein: RN181
E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181)

Gene: RN181, RNF181
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q9P0P0

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0016567 - protein ubiquitination
GO:0046872 - metal ion binding
GO:0051865 - protein autoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849467

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.925

High

1349753

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

919885

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.857

High

851898

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

895934

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.800

High

475216

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.713

High

924199

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

13

Small-scale

0.713

High

1282357

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1298010

RN145
RING finger protein 145

1

11

High-throughput

0.691

High

476491

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

896555

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1349747

RN181
E3 ubiquitin-protein ligase RNF181

1

11

Small-scale

0.647

High

1200871

PAQR2
Adiponectin receptor protein 2

3

0

High-throughput

0.638

High

439941

ITA2B
Integrin alpha-IIb

2

1

Small-scale

0.629

High

832049

PSB3
Proteasome subunit beta type-3

2

7

High-throughput

0.628

High

1138926

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

1205144

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

8

High-throughput

0.618

High

656138

PSB9
Proteasome subunit beta type-9

3

5

High-throughput

0.609

High

1349756

FBX7
F-box only protein 7

2

0

High-throughput

0.602

High

1241899

CTL5
Choline transporter-like protein 5

2

1

High-throughput

0.574

High

1315463

CAR11
Caspase recruitment domain-containing protein 11

1

2

Small-scale

0.561

High

365291

MT2
Metallothionein-2

1

2

Small-scale

0.552

High

170499

TIF1A
Transcription intermediary factor 1-alpha

1

4

High-throughput

0.541

High

1036362

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

High-throughput

0.541

High

1198482

PEG10
Retrotransposon-derived protein PEG10

1

1

High-throughput

0.541

High

1317091

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.541

High

1318354

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

6

High-throughput

0.541

High

154254

CHK1
Serine/threonine-protein kinase Chk1

1

2

High-throughput

0.536

High

156365

PSA7
Proteasome subunit alpha type-7

1

5

High-throughput

0.536

High

311773

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

1121390

AKIR2
Akirin-2

1

1

High-throughput

0.536

High

1316334

GNB1L
Guanine nucleotide-binding protein subunit beta-like protein 1

1

3

High-throughput

0.536

High

1344660

PICK1
PRKCA-binding protein

1

1

High-throughput

0.536

High

275353

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

High-throughput

0.518

High

912792

BTG1
Protein BTG1

1

0

High-throughput

0.518

High

1329145

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.518

High

1167354

GDPD4
Glycerophosphodiester phosphodiesterase domain-containing protein 4

1

1

High-throughput

0.515

High

299534

KLH18
Kelch-like protein 18

1

0

High-throughput

0.513

High

316353

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.513

High

647697

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

983079

ICA69
Islet cell autoantigen 1

1

0

High-throughput

0.513

High

995735

ADCY2
Adenylate cyclase type 2

1

0

High-throughput

0.513

High

1037192

TRPC3
Short transient receptor potential channel 3

1

0

High-throughput

0.513

High

1183831

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

High-throughput

0.513

High

1287816

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

1349752

MTMR6
Myotubularin-related protein 6

1

0

High-throughput

0.513

High

1335028

CLK4
Dual specificity protein kinase CLK4

1

2

High-throughput

0.494

High

303594

OR6B1
Olfactory receptor 6B1

1

2

High-throughput

0.489

High

893614

SEM1
26S proteasome complex subunit SEM1

1

1

Small-scale

0.489

High

1129407

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

4

High-throughput

0.489

High

1203063

LONP2
Lon protease homolog 2, peroxisomal

1

3

High-throughput

0.489

High

1243505

TRPV3
Transient receptor potential cation channel subfamily V member 3

1

1

High-throughput

0.489

High

1245445

OR5M3
Olfactory receptor 5M3

1

1

High-throughput

0.489

High

1245446

OR5M8
Olfactory receptor 5M8

1

1

High-throughput

0.489

High

1261904

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

High-throughput

0.489

High

1292423

TRM2B
tRNA

1

1

High-throughput

0.489

High

1334378

AKIR1
Akirin-1

1

1

High-throughput

0.489

High

1349748

CSC1
Calcium permeable stress-gated cation channel 1

1

1

High-throughput

0.489

High

1349749

NAGK
N-acetyl-D-glucosamine kinase

1

2

High-throughput

0.489

High

1349757

KIF3A
Kinesin-like protein KIF3A

1

1

High-throughput

0.489

High

363931

ALBU
Albumin

1

1

Small-scale

0.481

High

388006

MT1E
Metallothionein-1E

1

2

Small-scale

0.481

High

945825

MT1H
Metallothionein-1H

1

2

Small-scale

0.481

High

330291

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.480

High

161725

GAK
Cyclin-G-associated kinase

1

4

High-throughput

0.479

High

370595

ESR1
Estrogen receptor

1

7

Small-scale

0.479

High

452286

HMOX1
Heme oxygenase 1

1

1

Small-scale

0.479

High

785577

ACTY
Beta-centractin

1

1

High-throughput

0.479

High

832170

PSB2
Proteasome subunit beta type-2

1

8

Small-scale

0.479

High

897141

ACTZ
Alpha-centractin

1

1

High-throughput

0.479

High

913809

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.479

High

929702

RACK1
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

1039346

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.479

High

1124959

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.479

High

1271206

RBP56
TATA-binding protein-associated factor 2N

1

2

High-throughput

0.479

High

1305301

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1233683

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.470

High

806204

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.460

High

532633

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

574462

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.458

High

591127

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

874605

XPO2
Exportin-2

1

0

High-throughput

0.458

High

910950

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

991905

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.458

High

1051488

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1133501

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

1189811

MYH14
Myosin-14

1

0

High-throughput

0.458

High

1349751

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.458

High

1349755

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

130171

ELL2
RNA polymerase II elongation factor ELL2

1

1

Small-scale

0.439

High

361940

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

Small-scale

0.439

High

709089

MCM7
DNA replication licensing factor MCM7

1

2

Small-scale

0.439

High

198738

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.437

High

211264

BUB3
Mitotic checkpoint protein BUB3

1

3

High-throughput

0.437

High

309119

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.437

High

419066

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.437

High

451320

TPM1
Tropomyosin alpha-1 chain

1

2

High-throughput

0.437

High

508752

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.437

High

538431

ENPL
Endoplasmin

1

2

High-throughput

0.437

High

573508

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.437

High

646495

PON1
Serum paraoxonase/arylesterase 1

1

1

High-throughput

0.437

High

816119

ATPO
ATP synthase subunit O, mitochondrial

1

1

High-throughput

0.437

High

826922

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.437

High

843416

TCPD
T-complex protein 1 subunit delta

1

4

High-throughput

0.437

High

891613

MYL6
Myosin light polypeptide 6

1

2

High-throughput

0.437

High

932065

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.437

High

1065587

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.437

High

1115592

GLYR1
Cytokine-like nuclear factor N-PAC

1

2

High-throughput

0.437

High

1349758

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

2

High-throughput

0.437

High

234155

FADS1
Acyl-CoA

2

0

High-throughput

0.328

High

687148

CDD
Cytidine deaminase

2

0

High-throughput

0.328

High

1331948

VIAAT
Vesicular inhibitory amino acid transporter

2

0

High-throughput

0.328

High

948522

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.282

High

1078207

NPY5R
Neuropeptide Y receptor type 5

1

0

High-throughput

0.282

High

216626

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.279

Low

259628

HMMR
Hyaluronan mediated motility receptor

1

0

High-throughput

0.279

Low

313963

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.279

Low

886925

T2R38
Taste receptor type 2 member 38

1

0

High-throughput

0.279

Low

953183

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1168328

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1239971

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1240580

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.279

Low

1288426

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1309946

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.279

Low

1316107

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

0

High-throughput

0.279

Low

1332178

NSUN3
tRNA

1

0

High-throughput

0.279

Low

1349750

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.279

Low

1349754

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

1149582

SL9A4
Sodium/hydrogen exchanger 4

1

0

High-throughput

0.269

Low

330367

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

Small-scale

0.251

Low

936091

HBA
Hemoglobin subunit alpha

1

0

Small-scale

0.251

Low

278674

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.249

Low

559519

H13
Histone H1.3

1

0

High-throughput

0.249

Low

819040

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

911758

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.249

Low

1051698

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.249

Low

1348815

ARP10
Actin-related protein 10

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024