HitPredict

Interactor 1: KAPCA (P17612)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: PRKACA

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 351 Hs			1 618
+	Hs
		545209 KAPCB_HUMAN (1-351): 7.27e-164: 463: 92.88		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		568605 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		568619 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		682177 AKT2_HUMAN (18-343): 1.61e-150: 434: 38.79		RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70
+	Hs
		681775 AKT1_HUMAN (7-347): 2.89e-149: 430: 38.79		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		616691 KS6B1_HUMAN (2-351): 1.99e-141: 412: 33.24		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Sc
		350832 KAPC_YEAST (33-351): 2.01e-142: 410: 48.76		YPT1_YEAST (416-588): 9.61e-32: 123: 18.54
+	Hs
		568611 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		568800 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		436148 KAPCA_HUMAN (1-351): 9.98e-166: 467: 100.00		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		623871 KPCL_HUMAN (6-351): 1.39e-145: 428: 36.59		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		564425 AKT2_HUMAN (18-343): 1.61e-150: 434: 38.79		RHOQ_HUMAN (5-169): 2.02e-10: 62.8: 26.26