HitPredict

Interactor 1: DNMT1 (P13864)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (Met-1) (EC 2.1.1.37) (DNA methyltransferase MmuI) (DNA MTase MmuI) (M.MmuI) (MCMT)
Gene: DNMT1

Interactor 2: CUL3 (Q9JLV5)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23086144
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0071230 - cellular response to amino acid stimulus
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1620 Mm			1 768
+	Hs
		684994 DNMT1_HUMAN (1-1620): 0: 1849: 76.87		CUL3_HUMAN (1-768): 0: 947: 99.48
+	Hs
		684995 DNMT1_HUMAN (1-1620): 0: 1849: 76.87		CUL4A_HUMAN (10-768): 0: 802: 38.45
+	Hs
		684996 DNMT1_HUMAN (1-1620): 0: 1849: 76.87		CUL4B_HUMAN (5-768): 0: 796: 36.77
+	Hs
		1114678 SMC3_HUMAN (113-747): 1.72e-33: 143: 12.61		CUL3_HUMAN (1-768): 0: 947: 99.48
+	Hs
		1113761 THOC2_HUMAN (2-314): 4.6e-30: 132: 14.01		CUL3_HUMAN (1-768): 0: 947: 99.48
+	Hs
		1113540 RBBP6_HUMAN (2-405): 6.07e-09: 63.1: 8.15		CUL3_HUMAN (1-768): 0: 947: 99.48
+	Hs
		1115150 SMC3_HUMAN (113-747): 1.72e-33: 143: 12.61		CUL4A_HUMAN (10-768): 0: 802: 38.45
+	Mm
		58989 RBBP6_MOUSE (1-407): 8.76e-11: 69.2: 12.25		CUL4B_MOUSE (5-768): 0: 796: 36.64
+	Hs
		1113029 SMC3_HUMAN (113-747): 1.72e-33: 143: 12.61		CUL2_HUMAN (30-768): 0: 670: 26.30
+	Hs
		551615 NFH_HUMAN (6-358): 8.68e-17: 88.9: 13.37		CUL1_HUMAN (18-768): 0: 707: 29.94
+	Hs
		1112572 RBBP6_HUMAN (2-405): 6.07e-09: 63.1: 8.15		CUL1_HUMAN (18-768): 0: 707: 29.94