HitPredict

Interactor 1: PTN2 (P17706)
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
Gene: PTPN2

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 26026268, 29386185, 31488827, 35091679, 36523164, 12359225, 36660824
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~Y_phosphatase
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 5 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 415
Hs

1 770
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024