Protein: UBR3
E3 ubiquitin-protein ligase UBR3 (EC 2.3.2.27) (N-recognin-3) (RING-type E3 ubiquitin transferase UBR3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650)

Gene: UBR3
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q6ZT12

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001701 - in utero embryonic development
GO:0001967 - suckling behavior
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884355

UBE2A
Ubiquitin-conjugating enzyme E2 A

3

14

Small-scale

0.850

High

990973

UBE2B
Ubiquitin-conjugating enzyme E2 B

3

14

Small-scale

0.850

High

212433

SPIT2
Kunitz-type protease inhibitor 2

4

1

High-throughput

0.691

High

156391

HSPB6
Heat shock protein beta-6

3

1

High-throughput

0.667

High

180999

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

2

High-throughput

0.667

High

1144621

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

1

High-throughput

0.667

High

1254282

ZSC32
Zinc finger and SCAN domain-containing protein 32

3

1

High-throughput

0.667

High

970685

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

13

Small-scale

0.647

High

982219

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

11

High-throughput

0.647

High

746550

IFNA8
Interferon alpha-8

4

6

High-throughput

0.630

High

1254287

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

2

1

High-throughput

0.628

High

856759

BAG6
Large proline-rich protein BAG6

1

1

Small-scale

0.618

High

1254277

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

8

Small-scale

0.618

High

411163

WNT1
Proto-oncogene Wnt-1

2

2

High-throughput

0.612

High

378321

IFNA5
Interferon alpha-5

3

6

High-throughput

0.609

High

378291

IFN21
Interferon alpha-21

3

6

High-throughput

0.604

High

484823

HXB7
Homeobox protein Hox-B7

3

2

High-throughput

0.604

High

1254250

CIR1
Corepressor interacting with RBPJ 1

2

0

High-throughput

0.602

High

1254283

ABI2
Abl interactor 2

2

0

High-throughput

0.602

High

378264

IFN10
Interferon alpha-10

2

6

High-throughput

0.574

High

1180909

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

2

2

High-throughput

0.574

High

1101546

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

1

High-throughput

0.549

High

1177156

MICB
MHC class I polypeptide-related sequence B

2

1

High-throughput

0.549

High

1254286

EGFL7
Epidermal growth factor-like protein 7

2

1

High-throughput

0.549

High

1254272

KIRR1
Kin of IRRE-like protein 1

2

1

High-throughput

0.537

High

377313

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

1

1

High-throughput

0.536

High

1248526

KIRR2
Kin of IRRE-like protein 2

1

1

High-throughput

0.536

High

1254270

PDLI5
PDZ and LIM domain protein 5

1

1

High-throughput

0.536

High

1254281

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

1

High-throughput

0.536

High

1254251

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

High-throughput

0.518

High

230977

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

250277

VINEX
Vinexin

1

0

High-throughput

0.513

High

270944

CLAP2
CLIP-associating protein 2

1

0

High-throughput

0.513

High

555406

SKI
Ski oncogene

1

0

High-throughput

0.513

High

563961

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

600620

NAGAB
Alpha-N-acetylgalactosaminidase

1

0

High-throughput

0.513

High

702402

CYTD
Cystatin-D

1

0

High-throughput

0.513

High

1124160

LY6D
Lymphocyte antigen 6D

1

0

High-throughput

0.513

High

1238235

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.513

High

1254252

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

0

High-throughput

0.513

High

1254255

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.513

High

1254257

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.513

High

1254262

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.513

High

1254268

F163A
Protein FAM163A

1

0

High-throughput

0.513

High

1254275

EFC11
EF-hand calcium-binding domain-containing protein 11

1

0

High-throughput

0.513

High

1254279

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

1254280

SHLB2
Endophilin-B2

1

0

High-throughput

0.513

High

697154

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.501

High

343717

FGF19
Fibroblast growth factor 19

1

0

High-throughput

0.493

High

1254264

GTSF1
Gametocyte-specific factor 1

1

0

High-throughput

0.493

High

1254273

SCYL1
N-terminal kinase-like protein

1

0

High-throughput

0.493

High

378254

IFNA2
Interferon alpha-2

1

6

High-throughput

0.489

High

378272

IFNA7
Interferon alpha-7

1

6

High-throughput

0.489

High

420265

IFN16
Interferon alpha-16

1

6

High-throughput

0.489

High

611741

BMP7
Bone morphogenetic protein 7

1

3

High-throughput

0.489

High

848659

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1007488

KRT83
Keratin, type II cuticular Hb3

1

1

High-throughput

0.489

High

1090097

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

2

High-throughput

0.489

High

1161846

AMHR2
Anti-Muellerian hormone type-2 receptor

1

1

High-throughput

0.489

High

1254271

AJUBA
LIM domain-containing protein ajuba

1

1

High-throughput

0.489

High

703951

DUS1
Dual specificity protein phosphatase 1

1

1

Small-scale

0.479

High

1254246

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1254285

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1194612

DUS28
Dual specificity phosphatase 28

1

2

High-throughput

0.470

High

869050

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

1023254

RBM3
RNA-binding protein 3

1

0

Small-scale

0.458

High

1254259

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1254265

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1254266

ESR2
Estrogen receptor beta

1

1

High-throughput

0.445

High

1254284

MAGC2
Melanoma-associated antigen C2

1

1

Small-scale

0.439

High

662598

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

Small-scale

0.426

High

888906

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.426

High

1254261

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.426

High

1254263

NEUFC
Neuferricin

1

0

High-throughput

0.426

High

1254288

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

628365

CD33
Myeloid cell surface antigen CD33

1

1

High-throughput

0.407

High

1254248

SL9B2
Sodium/hydrogen exchanger 9B2

1

1

High-throughput

0.407

High

1254260

VGLU3
Vesicular glutamate transporter 3

1

2

High-throughput

0.407

High

1242586

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

4

0

High-throughput

0.360

High

658524

GLRA2
Glycine receptor subunit alpha-2

3

0

High-throughput

0.347

High

1216470

AHDC1
Transcription factor Gibbin

3

0

High-throughput

0.347

High

1254253

F219A
Protein FAM219A

3

0

High-throughput

0.347

High

1254269

RBM18
Probable RNA-binding protein 18

3

0

High-throughput

0.347

High

388540

CRP

3

0

High-throughput

0.345

High

1254256

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

1254274

MERB1
bMERB domain-containing protein 1

2

0

High-throughput

0.328

High

1254278

TPIP1
p53-regulated apoptosis-inducing protein 1

2

0

High-throughput

0.319

High

1254258

TM87A
Transmembrane protein 87A

2

0

High-throughput

0.313

High

67296

YJEN3
YjeF N-terminal domain-containing protein 3

1

0

High-throughput

0.279

Low

350476

GPAN1
G patch domain and ankyrin repeat-containing protein 1

1

0

High-throughput

0.279

Low

402314

PA21B
Phospholipase A2

1

0

High-throughput

0.279

Low

1053186

ZP2
Zona pellucida sperm-binding protein 2

1

0

High-throughput

0.279

Low

1128976

INSL4
Early placenta insulin-like peptide

1

0

High-throughput

0.279

Low

1191536

TBRG1
Transforming growth factor beta regulator 1

1

0

High-throughput

0.279

Low

1207673

MIIP
Migration and invasion-inhibitory protein

1

0

High-throughput

0.279

Low

1234180

ISK14
Serine protease inhibitor Kazal-type 14

1

0

High-throughput

0.279

Low

1254249

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.279

Low

1254254

FA43A
Protein FAM43A

1

0

High-throughput

0.279

Low

1254267

LEAP2
Liver-expressed antimicrobial peptide 2

1

0

High-throughput

0.279

Low

1254276

CA198
Uncharacterized protein C1orf198

1

0

High-throughput

0.279

Low

1185979

SOAT
Sodium-dependent organic anion transporter

1

0

High-throughput

0.269

Low

1254247

CI139
Putative uncharacterized protein LINC02908

1

0

High-throughput

0.269

Low

515888

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.232

Low

1226923

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025