HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35271311, 22079093
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N, AAA_lid_3~Proteasome, AAA_lid_3~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Hs			1 255
+	Hs
		92603 E9PMD8_HUMAN (8-294): 0: 508: 95.47		PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00
+	Hs
		92605 E9PMD8_HUMAN (8-294): 0: 508: 95.47		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		92615 E9PMD8_HUMAN (8-294): 0: 508: 95.47		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		92604 E9PMD8_HUMAN (8-294): 0: 508: 95.47		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Dm
		820506 PRS4_DROME (5-433): 2.8e-136: 400: 42.49		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Dm
		1359403 Q9V405_DROME (6-438): 4.77e-130: 383: 37.64		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Hs
		572863 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		637835 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00
+	Dm
		820495 PRS4_DROME (5-433): 2.8e-136: 400: 42.49		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Hs
		572911 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		656193 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		893639 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		572859 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Hs
		638104 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Hs
		156216 PRS6A_HUMAN (1-439): 1.23e-136: 401: 100.00		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Hs
		156269 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Dm
		1278638 Q9V405_DROME (6-438): 4.77e-130: 383: 37.64		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Dm
		611634 PRS4_DROME (5-433): 2.8e-136: 400: 42.49		PSA71_DROME (8-184): 2.38e-32: 120: 36.72
+	Sp
		144489 PRS6A_SCHPO (27-439): 1.42e-129: 382: 71.74		PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00
+	Dm
		611655 Q9V405_DROME (6-438): 4.77e-130: 383: 37.64		PSA71_DROME (8-184): 2.38e-32: 120: 36.72