HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 192
+	Hs
		545198 PTN1_HUMAN (1-435): 0: 539: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		573643 PTN1_HUMAN (1-435): 0: 539: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		573659 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		573644 PTN1_HUMAN (1-435): 0: 539: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		573648 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436151 PTN1_HUMAN (1-435): 0: 539: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		545197 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		570523 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		570514 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436150 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		925235 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564498 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545345 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1020114 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		892338 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950951 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		893944 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900420 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436276 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		436268 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45