Protein: GBA1
Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Beta-glucosylceramidase 1) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.-) (D-glucosyl-N-acylsphingosine glucohydrolase) (Glucosylceramidase beta 1) (Imiglucerase) (Lysosomal cholesterol glycosyltransferase) (Lysosomal galactosylceramidase) (EC 3.2.1.46) (Lysosomal glycosylceramidase)

Gene: GBA1
Organism: Homo sapiens
Interactions: 125
UniProt ID: P04062

Gene Ontology (top 5):
GO:0004336 - galactosylceramidase activity
GO:0004348 - glucosylceramidase activity
GO:0005102 - signaling receptor binding
GO:0005124 - scavenger receptor binding
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375741

SCRB2
Lysosome membrane protein 2

3

1

Small-scale

0.656

High

375711

CALX
Calnexin

3

0

Small-scale

0.638

High

119848

RB27B
Ras-related protein Rab-27B

2

1

High-throughput

0.628

High

375702

ENPL
Endoplasmin

2

1

Small-scale

0.611

High

375714

SYUA
Alpha-synuclein

2

0

Small-scale

0.603

High

375706

TCPA
T-complex protein 1 subunit alpha

2

1

Small-scale

0.601

High

375695

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.586

High

375697

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.584

High

375743

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.561

High

375696

NTRK1
High affinity nerve growth factor receptor

2

0

Small-scale

0.559

High

375719

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

375720

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.536

High

375721

RB27A
Ras-related protein Rab-27A

1

2

High-throughput

0.536

High

375729

1433G
14-3-3 protein gamma

1

1

High-throughput

0.536

High

375734

1433F
14-3-3 protein eta

1

1

High-throughput

0.536

High

375801

HYOU1
Hypoxia up-regulated protein 1

1

2

High-throughput

0.536

High

156439

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

361685

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

375698

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

375747

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.513

High

375760

FGD6
FYVE, RhoGEF and PH domain-containing protein 6

1

0

High-throughput

0.513

High

375766

INADL
InaD-like protein

1

0

High-throughput

0.513

High

375769

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.513

High

375772

ERP27
Endoplasmic reticulum resident protein 27

1

0

High-throughput

0.513

High

375783

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.513

High

375794

B4GT7
Beta-1,4-galactosyltransferase 7

1

0

High-throughput

0.513

High

375799

CNPY2
Protein canopy homolog 2

1

0

High-throughput

0.513

High

375718

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.501

High

375709

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.493

High

375752

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

2

High-throughput

0.489

High

375787

BMP2K
BMP-2-inducible protein kinase

1

1

High-throughput

0.489

High

375712

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

375731

TBB4B
Tubulin beta-4B chain

1

3

Small-scale

0.479

High

375737

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.479

High

375739

TBB2A
Tubulin beta-2A chain

1

3

Small-scale

0.479

High

375745

EEA1
Early endosome antigen 1

1

2

Small-scale

0.479

High

375749

TBB8
Tubulin beta-8 chain

1

3

Small-scale

0.479

High

375750

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.479

High

375751

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

Small-scale

0.479

High

375758

POTEE
POTE ankyrin domain family member E

1

1

Small-scale

0.479

High

375761

VP13C
Intermembrane lipid transfer protein VPS13C

1

1

Small-scale

0.479

High

375773

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

375796

MYH13
Myosin-13

1

1

Small-scale

0.479

High

375797

RAB21
Ras-related protein Rab-21

1

1

High-throughput

0.479

High

126992

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

204909

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

226222

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.458

High

375700

3BHS1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

1

0

Small-scale

0.458

High

375703

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

375705

HSP76
Heat shock 70 kDa protein 6

1

0

Small-scale

0.458

High

375708

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.458

High

375723

CATC
Dipeptidyl peptidase 1

1

0

Small-scale

0.458

High

375727

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

375728

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.458

High

375753

DEN4C
DENN domain-containing protein 4C

1

0

Small-scale

0.458

High

375763

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

375770

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

375778

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

375782

SG196
Protein O-mannose kinase

1

0

High-throughput

0.458

High

375788

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

375790

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.458

High

63087

POTEM
Putative POTE ankyrin domain family member M

1

2

Small-scale

0.437

High

69715

FHAD1
Forkhead-associated domain-containing protein 1

1

2

Small-scale

0.437

High

166658

CE290
Centrosomal protein of 290 kDa

1

2

Small-scale

0.437

High

375699

MYH8
Myosin-8

1

1

Small-scale

0.437

High

375730

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.437

High

375757

TBA3E
Tubulin alpha-3E chain

1

1

Small-scale

0.437

High

375767

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.437

High

375776

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.437

High

375781

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

375715

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.426

High

375793

PI4KB
Phosphatidylinositol 4-kinase beta

1

0

Small-scale

0.426

High

375726

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

375754

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.407

High

63984

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

328693

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.279

Low

375707

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.279

Low

375716

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.279

Low

375722

KS6A3
Ribosomal protein S6 kinase alpha-3

1

0

High-throughput

0.279

Low

375736

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.279

Low

375746

ZMY11
Zinc finger MYND domain-containing protein 11

1

0

High-throughput

0.279

Low

375755

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

0

High-throughput

0.279

Low

375756

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.279

Low

375774

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

0

High-throughput

0.279

Low

375784

JPH1
Junctophilin-1

1

0

High-throughput

0.279

Low

375789

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.279

Low

375798

GUC1B
Guanylyl cyclase-activating protein 2

1

0

High-throughput

0.279

Low

174533

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

58481

MEIOC
Meiosis-specific coiled-coil domain-containing protein MEIOC

1

0

Small-scale

0.249

Low

231040

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.249

Low

313721

SVIL
Supervillin

1

0

Small-scale

0.249

Low

375701

GFAP
Glial fibrillary acidic protein

1

0

Small-scale

0.249

Low

375704

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

375710

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

375713

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

375717

KI67
Proliferation marker protein Ki-67

1

0

Small-scale

0.249

Low

375724

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.249

Low

375725

UDB15
UDP-glucuronosyltransferase 2B15

1

0

Small-scale

0.249

Low

375732

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.249

Low

375733

IRX5
Iroquois-class homeodomain protein IRX-5

1

0

Small-scale

0.249

Low

375735

EF1A2
Elongation factor 1-alpha 2

1

0

Small-scale

0.249

Low

375738

DGKZ
Diacylglycerol kinase zeta

1

0

Small-scale

0.249

Low

375740

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.249

Low

375742

ZN273
Zinc finger protein 273

1

0

Small-scale

0.249

Low

375744

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

Small-scale

0.249

Low

375748

IAH1
Isoamyl acetate-hydrolyzing esterase 1 homolog

1

0

Small-scale

0.249

Low

375759

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

375762

GPBP1
Vasculin

1

0

Small-scale

0.249

Low

375764

FMR1N
FMR1 neighbor protein

1

0

Small-scale

0.249

Low

375765

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

375768

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.249

Low

375771

RHDF1
Inactive rhomboid protein 1

1

0

Small-scale

0.249

Low

375775

CFA44
Cilia- and flagella-associated protein 44

1

0

Small-scale

0.249

Low

375777

EYA1
Eyes absent homolog 1

1

0

High-throughput

0.249

Low

375779

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

0

Small-scale

0.249

Low

375780

SNX25
Sorting nexin-25

1

0

Small-scale

0.249

Low

375785

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

375786

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

375791

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

375792

JCAD
Junctional cadherin 5-associated protein

1

0

Small-scale

0.249

Low

375795

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.249

Low

375800

ZN175
Zinc finger protein 175

1

0

Small-scale

0.249

Low

375802

SPIN1
Spindlin-1

1

0

Small-scale

0.249

Low

375803

S12A7
Solute carrier family 12 member 7

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024