Interactor 1: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Interactor 2: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 31839598, 17051221, 24847884
Identification Methods cross-linking study, molecular sieving, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Peptidase_M16~Peptidase_M16, Peptidase_M16~Peptidase_M16_C, Peptidase_M16~Peptidase_M16_M, Peptidase_M16~PqqF-like_C_4, Peptidase_M16_C~Peptidase_M16_C, Peptidase_M16_C~Peptidase_M16_M, Peptidase_M16_M~Peptidase_M16_M, Peptidase_M16_M~PqqF-like_C_4
Common GO terms GO:0001540 - amyloid-beta binding
GO:0001618 - virus receptor activity
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
and 37 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1019
Hs

1 1019
+ Hs
+ Sc
+ Zm
+ Dm
+ Zm
+ Mm
+ Mm
+ Hs
+ Hs
+ Dm

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Last updated: 11Aug2025