Interactor 1: MPPB (O75439)
Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)
Gene: PMPCB

Interactor 2: MPPA (Q10713)
Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55)
Gene: PMPCA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.895

The method score is based on:

Property Details
Experiments 28514442, 32877691, 33961781, 35575683
Identification Methods affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Peptidase_M16~Peptidase_M16, Peptidase_M16~Peptidase_M16_C, Peptidase_M16_C~Peptidase_M16_C
Common GO terms GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006627 - protein processing involved in protein targeting to mitochondrion
GO:0017087 - mitochondrial processing peptidase complex
and 1 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 489
Hs

1 525
+ Hs
+ Mm
+ Dm
+ Hs
+ Mm
+ Hs
+ Ce
+ Sc
+ Mm
+ Dm
+ Hs
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025