HitPredict

Interactor 1: SON (P18583)
Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)
Gene: SON

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck GO:0043484 - regulation of RNA splicing
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2426 Hs			1 499
+	Hs
		833876 PRP4K_HUMAN (1837-2057): 3.72e-14: 80.7: 21.53		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		311795 TACC2_HUMAN (3-1233): 8.43e-12: 73.4: 9.06		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		833730 PRP4K_HUMAN (1837-2057): 3.72e-14: 80.7: 21.53		CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31
+	Hs
		70875 B2RWP4_HUMAN (3-1246): 3.21e-10: 68.4: 7.79		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Dm
		834215 Q9W1A9_DROME (988-1900): 2.02e-31: 138: 11.67		DOA_DROME (8-494): 4.91e-114: 357: 51.83
+	Hs
		834036 PRP4K_HUMAN (1837-2057): 3.72e-14: 80.7: 21.53		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625528 TITIN_HUMAN (735-1660): 9.25e-11: 70.2: 9.62		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		625662 NCOR2_HUMAN (1181-2323): 1.92e-09: 65.7: 8.84		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Sp
		999904 THO2_SCHPO (1667-2041): 9.74e-18: 93: 19.30		LKH1_SCHPO (25-481): 2.39e-116: 359: 33.05
+	Dm
		834194 Q9VC60_DROME (1833-2057): 5.61e-11: 69.9: 24.28		DOA_DROME (8-494): 4.91e-114: 357: 51.83
+	Hs
		1264773 TITIN_HUMAN (735-1660): 9.25e-11: 70.2: 9.62		DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20
+	Hs
		1044321 PCLO_HUMAN (1506-2320): 1.35e-17: 92.7: 7.19		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1268591 TARA_HUMAN (1779-2076): 1.94e-09: 65.7: 18.75		DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20
+	Dm
		618408 Q9VC60_DROME (1833-2057): 5.61e-11: 69.9: 24.28		CDK1_DROME (160-483): 3.99e-113: 338: 25.00
+	Hs
		1043938 RB12B_HUMAN (1805-2051): 1.21e-11: 72.6: 18.75		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1044147 TARA_HUMAN (1779-2076): 1.94e-09: 65.7: 18.75		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1044317 NCOR2_HUMAN (1181-2323): 1.92e-09: 65.7: 8.84		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50