HitPredict

Interactor 1: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF

Interactor 2: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.59 1.00 0.770

The method score is based on:

Property Details
Experiments 27034005, 35512704
Identification Methods affinity chromatography technology, split luciferase complementation, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Ras, PK_Tyr_Ser-Thr~Ras, RBD~Ras
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0070374 - positive regulation of ERK1 and ERK2 cascade
GO:0098978 - glutamatergic synapse
GO:2000301 - negative regulation of synaptic vesicle exocytosis
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 766
Hs

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Last updated: 11Aug2025