HitPredict

Interactor 1: PGTB1 (P18898)
Geranylgeranyl transferase type-1 subunit beta (GGTase-I-beta) (EC 2.5.1.59) (Cell division cycle protein 43) (Geranylgeranyl transferase type I subunit beta) (RAS proteins geranylgeranyltransferase subunit beta) (Type I protein geranyl-geranyltransferase subunit beta) (PGGTase I beta)
Gene: CDC43

Interactor 2: FNTA (P29703)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (PFTase/PGGTase I alpha) (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
Gene: RAM2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 10688190, 1400380, 20826334, 26771498, 16554755, 18719252, 37968396, 22940862, 16429126
Identification Methods two hybrid, biochemical, affinity chromatography technology, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PPTA~Prenyltrans
Common GO terms GO:0004662 - CAAX-protein geranylgeranyltransferase activity
GO:0005737 - cytoplasm
GO:0005953 - CAAX-protein geranylgeranyltransferase complex
GO:0018344 - protein geranylgeranylation
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 376
Sc

1 316
+ Sc
+ Hs
+ Rn
+ Dm
+ At
+ Ce
+ Hs
+ Rn
+ Ce
+ Sp
+ Sp
+ Hs
+ Dm
+ Sc
+ Rn
+ At
+ Hs
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024